Month: July 2019


JapanSouth Korea feud takes dangerous turn as Trump stays quiet


first_img Advertising Japan-South Korea feud takes dangerous turn as Trump stays quiet US President Donald Trump has questioned America’s open-ended troop deployments in Japan and South Korea and his administration has been conspicuously absent when his Asian allies bicker. (File/AP Photo/Susan Walsh)For decades, Japan and South Korea have managed to keep their feuds largely limited to rhetorical barbs and diplomatic snubs. Now, with the U.S. increasingly sitting on the sidelines, it’s drifting toward economic conflict. Advertising Karnataka trust vote today: Speaker’s call on resignations, says SC, but gives rebel MLAs a shield After Masood Azhar blacklisting, more isolation for Pakistan Karnataka trust vote today: Speaker’s call on resignations, says SC, but gives rebel MLAs a shield Cabinet asks finance panel to consider securing funds for defence Trump Needs Them to Be Friends, But Japan and South Korea FeudThe U.S. has traditionally stepped in when tensions have become heated between two of Asia’s largest economies as they all confront security threats from North Korea and the ever-expanding shadow of China’s military in the region.But President Donald Trump has questioned America’s open-ended troop deployments in Japan and South Korea and his administration has been conspicuously absent when his Asian allies bicker. Trump was in Japan and South Korea over the past week but made no public statements to ease the conflict, which might be interpreted by Seoul and Tokyo as license to keep on sparring, Sneider said.American Responsibilities“Americans have always understood that the escalation of tensions between our two principle allies in northeast Asia is a threat to our own national security interests,” Sneider said. “This government has abandoned its responsibility.”Why Japan and South Korea Still Spar Over History More Explained Their dispute over what they see as proper contrition for Japan’s 1910-1945 colonial rule over the Korean Peninsula changed Thursday when export restrictions from Prime Minister Shinzo Abe’s government took effect. The measures can curb the supply of highly specialized products needed to make semiconductors and computer displays — an economic broadside in a fight that has so far been mostly a war of words.Tokyo contends that South Korea started the latest dispute when its courts last year ruled that Japanese companies must compensate Koreans conscripted to work in factories and mines for Japan’s imperial war machine. The worry now is that tensions between the major trading partners and U.S. allies could spiral out of control.“This is starting down the road toward economic warfare, and it’s very dangerous,” said Daniel Sneider, a lecturer in international policy at Stanford University who has written about how Japanese and Koreans view their shared history. Cabinet asks finance panel to consider securing funds for defence After Masood Azhar blacklisting, more isolation for Pakistan By Bloomberg | Published: July 4, 2019 10:23:55 am That changed with the South Korea Supreme Court decision, which initially affected 18 claimants who won compensation ranging from about $88,000 to $134,000 each. South Korean President Moon Jae-in has argued the treaty doesn’t prevent Koreans from suing Japanese firms and that the court decisions should be respected.The lawsuits could grow, with historians estimating hundreds of thousands of Koreans were used as forced labor. More than a dozen such cases are already pending in South Korea involving about 70 companies, according to the Japanese Ministry of Foreign Affairs.Japan called for invoking the arbitration process under the treaty and South Korea later proposed a joint fund. That didn’t sit well in Tokyo after Moon’s government effectively shut down a previous fund brokered in 2015 with Japan for compensation and a personal apology from Abe to the women forced into sexual servitude.‘Serious Implications’“The issue of conscripted laborers is not a historical issue, but a question of whether an international agreement between nations is maintained,” Abe said Wednesday about the dispute.The move to restrict chip material exports to South Korea could have “serious implications” for global supply chains and disrupt production at South Korean technology companies including Samsung Electronics and SK Hynix, Moody’s Investors Service wrote in a report published Tuesday. The companies have downplayed the matter but saw their shares fall Tuesday on the news.Japan’s Export Restrictions Threaten Blow to South Korea TechSouth Korea is looking at making the materials on its own. South Korea “will strongly pursue localization through technological development and intensive investment in about 100 essential materials,” South Korean Finance Minister Hong said.Kak-Soo Shin, who was at the front line of the disputes when he served as South Korea’s ambassador to Japan from 2011 to 2013, said the current friction could be “heralding a very dangerous and vicious cycle of escalation.” A State Department official, who asked not to be identified, said it is crucial for South Korea, Japan and the U.S. to maintain close relationships in the face of shared regional challenges.South Korea will consider “corresponding measures” if Japan doesn’t withdraw restrictions on some tech material exports, Finance Minister Hong Nam-ki said in an interview with local CBS Radio. The Ministry of Trade has started a review of the grounds for filing a complaint with the World Trade Organization, with Trade Minister Yoo Myung-hee canceling her planned trip to Latin America to help manage the matter, Yonhap News reported, citing a government official.The U.S. helped broker the 1965 treaty establishing ties between Japan and South Korea that included a payment from Tokyo of about $300 million — $2.4 billion in today’s money. The pact said all claims are “settled completely and finally.” South Korea’s then autocratic government used the funding as seed money for its industries.But the treaty didn’t ease the deep emotions in South Korea over forced labor, as well as women forced into sexual servitude at Japanese Imperial Army brothels and a territorial dispute over a set of islets claimed by both countries. As tensions brewed, the two governments largely kept their often interdependent economic relations away from the fray. Best Of Express He advised South Korea to understand why Japan is frustrated over its response and warned Tokyo of starting “an irreparable crisis” that could impact their security, adding: “They should think earnestly who will benefit from this profound rift between Seoul and Tokyo.” Top News Advertising Taking stock of monsoon rain Post Comment(s)last_img read more


Trump says weekend deportation raids were very successful


first_imgTrump had vowed to launch mass deportation roundups over the weekend, causing immigrants and their advocates to brace for large numbers of arrests, but by Sunday evening there were only reports of low-profile operations in a few cities.“The ICE (Immigration and Customs Enforcement) raids were very successful,” Trump told reporters at a White House event. “People came into our country illegally … Many were felons. Many were convicted of crimes.”“Many, many were taken out on Sunday – you just didn’t know about it. … It was a very successful day but you didn’t see a lot of it. … Every person taken out had papers and we had court orders,” Trump added, without offering any evidence to support his statement. Trump says weekend deportation raids were 'very successful' The Trump administration said on Monday it was implementing new rules for immigrants seeking asylum, requiring them to first seek protection from a third country. (Erin Schaff/The New York Times)US President Donald Trump said on Monday that raids over the weekend aimed at immigrants who had been ordered deported were “very successful” even though much of the activity was not visible to the public. ‘Truth, justice have prevailed’: PM Modi on Kulbhushan Jadhav verdict Salve hails verdict, says ICJ protected Jadhav from being executed Salve hails verdict, says ICJ protected Jadhav from being executed Advertising Best Of Express Jharkhand court drops ‘donate Quran’ condition for bail to Ranchi woman over offensive post Jharkhand court drops ‘donate Quran’ condition for bail to Ranchi woman over offensive post center_img Reporting over the weekend suggested the ICE raids were narrower in scope than had been anticipated. New York Mayor Bill de Blasio said there were three ICE operations in his city on Saturday. There were unconfirmed reports of ICE actions in Denver and Miami.“We are doing targeted enforcement actions against specific individuals who have had their day in immigration court and have been ordered removed by an immigration judge,” Acting ICE Director Matt Albence told Fox News on Sunday when asked for an update.Mary Bauer at the Southern Poverty Law Center (SPLC) said there were no confirmed operations in large Southern cities such as Atlanta.There also were no reports of arrests from the American Immigration Council, which has lawyers on standby to give legal advice at the country’s largest family migrant detention center in Dilley, Texas. Top News ‘Truth, justice have prevailed’: PM Modi on Kulbhushan Jadhav verdict Advertising By Reuters |Reuters | Published: July 16, 2019 8:44:24 am The removal operations are meant to deter a surge in Central American families seeking asylum in the United States after fleeing poverty and gang violence in their home countries.The Trump administration said on Monday it was implementing new rules for immigrants seeking asylum, requiring them to first seek protection from a third country. Post Comment(s)last_img read more


Precision cancer drugs spark powerful immune response and boost effects of immunotherapy


first_img Source:https://www.icr.ac.uk/news-archive/precision-drugs-could-unmask-cancers-to-the-immune-system-and-boost-the-effects-of-immunotherapy Mar 11 2019Precision cancer drugs called PARP inhibitors have a previously unknown ability to boost the immune system, and could help many more patients benefit from immunotherapy, a new study reveals.Scientists found that PARP inhibitors sparked a powerful immune response when used against cancer cells with weaknesses in repairing their DNA.The study changes our understanding of how PARP inhibitors work – and suggests they could be used alongside immunotherapies to boost their effectiveness. Clinical trials have already started to assess this combination.Some patients have benefited dramatically from a new generation of immunotherapies – but often only between 10 and 20 per cent of patients will respond, with many others’ cancers able to hide from the immune system.Scientists at The Institute of Cancer Research, London, and the Institut Gustave Roussy, France, led by Professor Chris Lord and Dr Sophie Postal-Vinay, found that PARP inhibitors could unmask some of these cancers that can currently evade detection by immune cells.Their study is published in the Journal of Clinical Investigation and was funded by Breast Cancer Now and Cancer Research UK.PARP inhibitors such as olaparib block one of the systems which cells use to repair their DNA. They are designed to attack tumours that are already defective at DNA repair, especially ovarian and breast cancers in women with inherited BRCA mutations.The researchers looked at lung tumours taken from patients, and found those with deficiencies in their DNA repair contained significantly more immune cells within the tumours, compared with tumours in patients with a functioning DNA repair system. This suggested that the DNA repair mutations were stimulating an immune response against the tumours.They also studied cancer cells from non-small cell lung cancers and triple-negative breast cancers with mutations in DNA repair genes such as ERCC1 or BRCA, to assess whether PARP inhibitors could increase this immune response.When cancer cells with defective repair systems are treated with PARP inhibitors to block their remaining system of DNA repair, they can no longer repair any DNA damage so accumulate more and more DNA mutations until they die.The researchers found that the accumulation of DNA damage in cancer cells treated with PARP inhibitors triggered the release of various molecular signals that have the potential to attract immune cells to the tumour, suggesting that treatment with PARP inhibitors could enhance the immune response against these cancer cells.In one ERCC1-deficient cancer cell line, 24 out of the 50 signalling pathways that were activated after exposure to PARP inhibitors were related to the immune system.The scientists found that PARP inhibitors could potentially be used to treat lung cancers with faults in their DNA repair genes, in part because of these newly discovered effects on the immune system. By using PARP inhibitors alongside immunotherapy, this immune response could be further enhanced to kill the cancer cells more effectively.Related StoriesUnited Nations sounds alarm bell on drug-resistant infectionsA ‘homing beacon’ for cancer drugsCannabis users could be more tolerant to anesthesia agentsAs 30 to 50 per cent of patients with non-small cell lung cancer have a deficiency in the ERCC1 DNA repair system, this could open up a new, more effective ways of treating a large proportion of non-small cell lung cancer patients.Study leader Professor Chris Lord, Professor of Cancer Genomics at The Institute of Cancer Research, London, said:”The findings of this study substantially change our understanding of how PARP inhibitors work. We now know that they not only kill tumours by damaging their DNA, but also by attracting immune cells to attack them – acting as a sort of double-pronged attack.”Immunotherapy is a genuinely brilliant cancer treatment but generally only for the 10 to 20 per cent of people who respond to it. Finding the tumour is half of the battle in immunotherapy so by attracting the immune cells to the tumour, PARP inhibitors could enable the immunotherapy drug to target their attack.”Study co-leader Dr Sophie Postel-Vinay, Clinician Scientist and Medical Oncologist at Gustave Roussy, France, and The Institute of Cancer Research, London, said:”Our study found that PARP inhibitors enlist immune cells to aid in the killing of cancer cells. This provides a rationale for using PARP inhibitors alongside immunotherapies to further stimulate the immune response to cancer cells with DNA repair defects and enhance the therapeutic benefit of the treatment.””This will be evaluated in a clinical trial of lung, prostate and bladder cancers, which is starting later this year.”Dr Ian Walker, Director of Clinical Research at Cancer Research UK, said:”This study highlights the important role that research in the lab plays in helping us devise new clinical trials. Identifying new combinations that make cancer drugs more effective could open up many new treatment options for patients with cancers that are hard-to-treat, like lung cancer. This is an exciting development and we look forward to seeing if PARP inhibitors can improve survival for these patients.”Dr Kotryna Temcinaite, Research Communications Manager at Breast Cancer Now, said:”These are really promising findings that show once more just how important PARP inhibitors could be in treating a number of cancers. Not only do these drugs interfere with tumour cells’ ability to repair DNA but this study suggests they may have additional effects in initiating an immune response, which could then be exploited using other treatments.”Activating the immune system to attack tumours is an exciting approach that is beginning to show promise in breast cancer. We now look forward to seeing how the combination of PARP inhibitors and checkpoint inhibitors may work in clinical trials for breast cancer patients.”last_img read more


Cholesterol lowering drug can also help treat cancerassociated cachexia


first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Mar 19 2019Brazilian researchers have discovered that a drug regularly prescribed to control cholesterol can also be used to treat cachexia, or wasting syndrome, a condition characterized by rapid weight loss and muscle atrophy associated with extreme physical weakness. This condition is common among patients with chronic diseases such as cancer, heart failure and AIDS.The study was supported by FAPESP – São Paulo Research Foundation and has been published in Scientific Reports, an online journal owned by Springer Nature.”Our goal is to understand more comprehensively how cachexia develops and to explore the activity of drugs capable of slowing the process down,” said Miguel Luiz Batista Junior, a professor at the University of Mogi das Cruzes (UMC) in Brazil and the principal investigator for the study.According to Batista, previous research has shown that a process of adipose tissue remodeling known as browning occurs in patients with cachexia and that browning significantly contributes to the rapid loss of weight and fat. Through experiments with mice, researchers at the Adipose Tissue Biology Laboratory of UMC identified a key protein in this process and showed that atorvastatin can attenuate its effects.The study was conducted in collaboration with scientists at Federal University of Minas Gerais and University of Maringá in Brazil and University of Massachusetts and Boston University in the United States. Funding was awarded by the National Council for Scientific and Technological Development of Brazil (CNPq, an agency of the Ministry of Science, Technology, Innovation and Communications), Serrapilheira Institute, as well as FAPESP.Batista explained that white adipose tissue stores fat when surplus energy is available, while the main function of brown adipose tissue is thermoregulation and insulation.For this reason, in winter, it is important to eat more food or choose meals with a higher calorie content because brown adipose cells turn fat into body heat and regulate body temperature.Brown adipose cells are not the only cell type that can burn fat for thermoregulation. At times of intense cold, beige adipose cells may also go into action via the browning of white adipose tissue. The structure and function of the cells change during this process. They continue to store excess energy but prioritize fat burning to assist in thermoregulation.”In patients with cachexia, white adipose cells are transformed into beige cells. This is curious, since, in theory, the organism of a debilitated individual doesn’t benefit from a reduction in fat reserves,” Batista said.The physiological role and consequences of the browning process induced by cachexia are unknown. “This is one of our study’s two major contributions,” Batista said.TLR4TLR4 (toll-like receptor 4) is a protein that plays a key role in pathogen recognition, innate immunity activation and inflammatory responses. Because obesity, similar to cachexia, is associated with systemic inflammation, the authors of the study suspected that TLR4 might be linked to adipose tissue remodeling. “We set out to associate the action of TLR4 with cachexia,” Batista said.In a mouse model, the researchers used both genetic ablation and pharmacological inhibition of a receptor similar to human TLR4. They next induced lung cancer in genetically modified mice (without TLR4) and in control wild-type mice (with TLR4).Related StoriesBacteria in the birth canal linked to lower risk of ovarian cancerSugary drinks linked to cancer finds studyResearchers use AI to develop early gastric cancer endoscopic diagnosis system”We found that 28 days after the inoculation of cancer cells in their lungs, the wild-type mice with TLR4 had lost 12% of their body weight, a classic sign of cachexia,” Batista said.Cachexia was less severe in mice without TLR4. “These animals lost less weight and muscle mass. They also lived longer, even though tumor growth was the same as in the control group. It’s also important to note that no lung metastasis was detected among the genetically modified mice,” Batista said.An analysis of adipose cells from the two groups showed that browning had occurred in the control mice with TLR4. This process likely led to accelerated weight loss. “Adipose tissue was less altered in the genetically modified mice without TLR4. In other words, lack of the receptor significantly blocked the adipose tissue browning effect,” Batista said.AtorvastatinAtorvastatin is an inexpensive drug widely used to control cholesterol. Research performed in recent years has described the anti-inflammatory effects of atorvastatin, including the downregulation of TLR4 gene expression.The authors of the study decided to use a preclinical model to determine whether atorvastatin affects the development of cachexia in wild-type mice with TLR4 in a similar manner to its effect on genetically modified mice without TLR4. They induced lung cancer in two groups of wild-type mice. In the group not treated with atorvastatin, tumors developed, and symptoms of cachexia were observed.In mice treated with atorvastatin, the result was even better than that in genetically modified mice without TLR4.”Treatment with atorvastatin proved effective in extending survival, attenuating adipose tissue remodeling and reducing tumor growth [by 49.7%] in comparison with a control group not treated with the drug. We showed that atorvastatin had a direct effect on the action of TLR4, which inhibited adipose tissue browning and reduced tumor growth,” Batista said.”With regard to the prospects for treatment of cachexia, the results of the genetic and preclinical models were highly promising. We expect these results to encourage researchers to test the clinical use of atorvastatin in patients with cancer.”In a vast majority of cases, cachexia is associated with the terminal stage of chronic diseases. In 20% of these terminal patients, cachexia is the cause of death. Among patients with pancreatic, lung and gastrointestinal tumors, cachexia is observed in 60%-80% of cases.”Cachexia is irreversible once established. In cancer patients, the development of cachexia usually shows that death is approaching. The patient’s extreme debilitation almost always obliges the medical team to reduce medication or even to suspend radiation therapy or chemotherapy,” Batista said.”The cancer doctor’s priority isn’t to treat cachexia but to attack the tumor. However, knowing the causes of this severe metabolic syndrome can help us discover drugs that attenuate its effects and mitigate its tendency to prevent the continuity of oncological treatment.” Source:http://agencia.fapesp.br/drug-used-to-control-cholesterol-found-effective-against-cancer-associated-cachexia/30035/last_img read more


New nanotechnology approach shows promise in treating triple negative breast cancer


first_imgReviewed by James Ives, M.Psych. (Editor)Mar 22 2019Unlike the three most common forms of breast cancer, triple negative breast cancer has no currently approved targeted therapies for treatment. That was one of the reasons it was chosen as a disease area of focus for the Indiana University Precision Health Grand Challenge initiative, aimed to research and develop better treatments, cures or preventions, as quickly as possible.Xiongbin Lu, PhD, a researcher in the Vera Bradley Foundation Center for Breast Cancer Research at Indiana University School of Medicine, working in collaboration with researchers from the University of Maryland, recently reported several important findings related to triple negative breast cancer and its treatment future, in the prestigious journal Nature Nanotechnology.Related StoriesLiving with advanced breast cancerBacteria in the birth canal linked to lower risk of ovarian cancerNew study to ease plight of patients with advanced cancerAccording to the paper now available online, TP53 is the most frequently mutated gene in triple negative breast cancer, meaning it is fueling the growth of this aggressive form of breast cancer. However, the problem with trying to target mutated TP53, specifically, is that it is not a druggable target, because of its potential toxicity – or ability to kill – nearby healthy cells.In response, the scientists went searching for the next likely suspect to target, and found a neighboring gene to TP53, known as POLR2A, which is a viable target, but required some additional effort.Lu, also a researcher at the Indiana University Melvin and Bren Simon Cancer Center, said, “Think of POLR2A as both a checking and savings account. In a healthy cell, both accounts exist. In a triple negative breast cancer cell, only the checking account exists due to the partial deletion of this particular essential gene, and if you take it away, the individual cannot survive.”However, utilizing nanotechnology (scientific technology on a microscopic scale), the group created what is known as a nano-bomb targeting POLR2A. The nano-bomb is created in a form that is stable in serum and when an instance of the POLR2A inhibitor-containing nano-bomb is delivered into a triple negative breast cancer cell, the bomb grows to 100 times its normal size and through a controlled release, kills only the cancerous cell, leaving the healthy cells alive. Essentially, using Dr. Lu’s analogy, “leaving the checking account open.”Lu and a collaborator have patented this nanotechnology approach, which also has potential implications in other cancers that display the mutated TP53 gene, such as ovarian, lung and colorectal cancer. “We’re still in the early stages of research, but I am excited about this approach and its potential to lead to a targeted therapy option for women with triple negative breast cancer,” Lu said. Source:https://medicine.iu.edu/news/2019/03/iu-school-of-medicine-discovery-may-lead-to-precision-based-strategy-for-triple-negative-breast-cancer/last_img read more


Software framework designed to accelerate drug discovery wins IEEE International Scalable Computing


first_imgJha and his team concurrently screened a group of 16 closely related drug candidates from the study by running thousands of computational sequences on more than 32,000 computing cores. They ran the computations on the Blue Waters supercomputer at the National Center for Computing Applications, University of Illinois at Urbana-Champaign.In a real drug design scenario, many more compounds with a wider range of chemical properties would need to be investigated. The team members previously demonstrated that the workload management layer and runtime system underlying HTBAC could scale to handle 10,000 concurrent tasks.”HTBAC could support the concurrent screening of different compounds at unprecedented scales—both in the number of compounds and computational resources used,” said Jha. “We showed that HTBAC has the ability to solve a large number of drug candidates in essentially the same amount of time it would take to solve a smaller set, assuming the number of processors increases proportionally with the number of candidates.”This ability is made possible through HTBAC’s adaptive functionality, which allows it to execute the optimal algorithm depending on the properties of the drugs being investigated, improving the accuracy of the results and minimizing compute time.”The lead optimization stage usually considers on the order of 10,000 small molecules,” said Jha. “While experiment automation reduces the amount of time needed to calculate the binding affinities, HTBAC has the potential to cut this time (and cost) by an order of magnitude or more.”With HTBAC, TIES requires approximately 25,000 central processing unit (CPU) core hours for a single prediction. At least a 250 million core hours would be needed for a large-scale study to support a pharmaceutical drug screening campaign, with a typical turnaround time of about two weeks. HTBAC could facilitate running studies requiring sustained usage of millions of core hours per day. This year’s winner, “Enabling Trade-off Between Accuracy and Computational Cost: Adaptive Algorithms to Reduce Time to Clinical Insight,” is the result of a collaboration between chemists and computational and computer scientists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory, Rutgers University, and University College London. The team members were honored at the 18th IEEE/Association for Computing Machinery (ACM) International Symposium on Cluster, Cloud and Grid Computing held in Washington, DC, from May 1 to 4.”We developed a numerical computation methodology for accurately and rapidly evaluating the efficacy of different drug candidates,” said team member Shantenu Jha, chair of the Center for Data-Driven Discovery, part of Brookhaven Lab’s Computational Science Initiative. “Though we have not yet applied this methodology to design a new drug, we demonstrated that it could work at the large scales involved in the drug discovery process.”Drug discovery is kind of like designing a key to fit a lock. In order for a drug to be effective at treating a particular disease, it must tightly bind to a molecule—usually a protein—that is associated with that disease. Only then can the drug activate or inhibit the function of the target molecule. Researchers may screen 10,000 or more molecular compounds before finding any that have the desired biological activity. But these “lead” compounds often lack the potency, selectivity, or stability needed to become a drug. By modifying the chemical structure of these leads, researchers can design compounds with the appropriate drug-like properties. The designed drug candidates then move along the development pipeline to the preclinical testing stage. Of these candidates, only a small fraction enters the clinical trial phase, and only one ends up becoming an approved drug for patient use. Bringing a new drug to the market can take a decade or longer and cost billions of dollars. Overcoming drug design bottlenecks through computational scienceRecent advances in technology and knowledge have resulted in a new era of drug discovery—one that could significantly reduce the time and expense of the drug development process. Improvements in our understanding of the 3-D crystal structures of biological molecules and increases in computing power are making it possible to use computational methods to predict drug-target interactions. Individual patients respond differently to drugs. The ability to predict which treatment is best for a particular patient based on his or her genetic sequence is the goal of personalized medicine. Credit: Brookhaven National Laboratory A schematic of the drug development process, which progressively hones in on the most effective candidates from a large initial pool. Credit: Brookhaven National Laboratory In particular, a computer simulation technique called molecular dynamics has shown promise in accurately predicting the strength with which drug molecules bind to their targets (binding affinity). Molecular dynamics simulates how atoms and molecules move as they interact in their environment. In the case of drug discovery, the simulations reveal how drug molecules interact with their target protein and change the protein’s conformation, or shape, which determines its function. In other words, it would not make sense to continue simulations of a particular drug-protein interaction if the drug weakly binds the protein as compared to the other candidates. But it would make sense to allocate additional computational resources if a drug shows a high binding affinity.Supporting adaptive workflows at the large scales characteristic of drug discovery programs requires advanced computational capabilities. HTBAC provides such support through a flexible middleware software layer that enables the adaptive execution of algorithms. Currently, HTBAC supports two algorithms: enhanced sampling of molecular dynamics with approximation of continuum solvent (ESMACS) and thermodynamic integration with enhanced sampling (TIES). ESMACS, a computationally cheaper but less rigorous method than TIES, computes the binding strength of one drug to its target protein on the basis of molecular dynamics simulations. By contrast, TIES compares the relative binding affinities of two different drugs to the same protein. “ESMACS provides a rapid quantitative approach sensitive enough to determine binding affinities so we can eliminate poor binders, while TIES provides a more accurate method for investigating good binders as they are refined and improved,” said Jumana Dakka, a second-year Ph.D. student at Rutgers and a member of the RADICAL group. In order to determine which algorithm to execute, HTBAC analyzes the binding affinity calculations at runtime. This analysis informs decisions about the number of concurrent simulations to perform and whether stimulation steps should be added or removed for each drug candidate investigated.Putting the framework to the testJha’s team demonstrated how HTBAC could provide insight from drug candidate data on a short timescale by reproducing results from a collaborative study between University College London and the London-based pharmaceutical company GlaxoSmithKline to discover drug compounds that bind to the BRD4 protein. Known to play a key role in driving cancer and inflammatory diseases, the BRD4 protein is a major target of bromodomain-containing (BRD) inhibitors, a class of pharmaceutical drugs currently being evaluated in clinical trials. The researchers involved in this collaborative study are focusing on identifying promising new drugs to treat breast cancer while developing an understanding of why certain drugs fail in the presence of breast cancer gene mutations. Drug discovery is a lock-and-key problem in which the drug (key) must specifically fit the biological target (lock). Credit: Brookhaven National Laboratory Provided by Brookhaven National Laboratory Solutions to many real-world scientific and engineering problems—from improving weather models and designing new energy materials to understanding how the universe formed—require applications that can scale to a very large size and high performance. Each year, through its International Scalable Computing Challenge (SCALE), the Institute of Electrical and Electronics Engineers (IEEE) recognizes a project that advances application development and supporting infrastructure to enable the large-scale, high-performance computing needed to solve such problems. New computational method for drug discoverycenter_img The scientists investigated the chemical structures of 16 drugs based on the same tetrahydroquinoline (THQ) scaffold. On the left is a cartoon of the BRD4 protein bound to one of these drugs; on the right is a molecular representation of a drug with the THQ scaffold highlighted in magenta. Regions that are chemically modified between the drugs investigated in this study are labeled 1 to 4. Typically, only a small change is made to the chemical structure of one drug to the next. This conservative approach makes it easier for researchers to understand why one drug is effective, whereas another is not. Credit: Brookhaven National Laboratory When the University of College London–GlaxoSmithKline study concludes, Jha and his team hope to be given the experimental data on the tens of thousands of drug candidates, without knowing which candidate ended up being the best one. With this information, they could perform a blind test to determine whether HTBAC provides an improvement in compute time (for a given accuracy) over the existing automated methods for drug discovery. If necessary, they could then refine their methodology.Applying scalable computing to precision medicineHTBAC not only has the potential to improve the speed and accuracy of drug discovery in the pharmaceutical industry but also to improve individual patient outcomes in clinical settings. Using target proteins based on a patient’s genetic sequence, HTBAC could predict a patient’s response to different drug treatments. This personalized assessment could replace the traditional one-size-fits-all approach to medicine. For example, such predictions could help determine which cancer patients would actually benefit from chemotherapy, avoiding unnecessary toxicity.According to Jha, the computation time would have to be significantly reduced in order for physicians to clinically use HTBAC to treat their patients: “Our grand vision is to apply scalable computing techniques to personalized medicine. If we can use these techniques to optimize drugs and drug cocktails for each individual’s unique genetic makeup on the order of a few days, we will be empowered to treat diseases much more effectively.””Extreme-scale computing for precision medicine is an emerging area that CSI and Brookhaven at large have begun to tackle,” said CSI Director Kerstin Kleese van Dam. “This work is a great example of how technologies we originally developed to tackle DOE challenges can be applied to other domains of high national impact. We look forward to forming more strategic partnerships with other universities, pharmaceutical companies, and medical institutions in this important area that will transform the future of health care.” Citation: Software framework designed to accelerate drug discovery wins IEEE International Scalable Computing Challenge (2018, August 1) retrieved 18 July 2019 from https://phys.org/news/2018-08-software-framework-drug-discovery-ieee.html Shantenu Jha, chair of Brookhaven Lab’s Center for Data-Driven Discovery, and his team from Rutgers University and University College London designed a software framework for accurately and rapidly calculating how strongly drug candidates bind to their target proteins. The framework is aimed at solving the real-world problem of drug design—currently a lengthy and expensive process—and could have an impact on personalized medicine. Credit: Brookhaven National Laboratory This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Explore further However, these prediction capabilities are not yet operating at a large-enough scale or fast-enough speed for pharmaceutical companies to adopt them in their development process. “Translating these advances in predictive accuracy to impact industrial decision making requires that on the order of 10,000 binding affinities are calculated as quickly as possible, without the loss of accuracy,” said Jha. “Producing timely insight demands a computational efficiency that is predicated on the development of new algorithms and scalable software systems, and the smart allocation of supercomputing resources.”Jha and his collaborators at Rutgers University, where he is also a professor in the Electrical and Computer Engineering Department, and University College London designed a software framework to support the accurate and rapid calculation of binding affinities while optimizing the use of computational resources. This framework, called the High-Throughput Binding Affinity Calculator (HTBAC), builds upon the RADICAL-Cybertools project that Jha leads as principal investigator of Rutgers’ Research in Advanced Distributed Cyberinfrastructure and Applications Laboratory (RADICAL). The goal of RADICAL-Cybertools is to provide a suite of software building blocks to support the workflows of large-scale scientific applications on high-performance-computing platforms, which aggregate computing power to solve large computational problems that would otherwise be unsolvable because of the time required.In computer science, workflows refer to a series of processing steps necessary to complete a task or solve a problem. Especially for scientific workflows, it is important that the workflows are flexible so that they can dynamically adapt during runtime to provide the most accurate results while making efficient use of the available computing time. Such adaptive workflows are ideal for drug discovery because only the drugs with high binding affinities should be further evaluated.”The trade-off desired between the required accuracy and computational cost (time) changes throughout the drug’s discovery as the process moves from screening to lead selection and then lead optimization,” said Jha. “A significant number of compounds must be inexpensively screened to eliminate poor binders before more accurate methods are needed to discriminate the best binders. Providing the quickest time-to-solution requires monitoring the progress of the simulations and basing decisions about continued execution on scientific significance.” More information: Enabling Trade-offs Between Accuracy and Computational Cost: Adaptive Algorithms to Reduce Time to Clinical Insight: ccs.chem.ucl.ac.uk/sites/ccs.c … ale2018-ccgrid_0.pdfImplementing Adaptive Ensemble Biomolecular Applications at Scale: arxiv.org/pdf/1804.04736.pdflast_img read more


Walmart teams with Rakuten on digital book shop


first_img The Walmart eBooks website boasting more than six million titles along with audiobooks competes head-on with a core offering of rival Amazon.Subscriptions to the Walmart audiobook service were $9.99 monthly, compared to $14.95 for a comparable Audible service at Amazon.”The launch of Walmart eBooks by Rakuten Kobo marks a milestone for our strategic alliance,” Rakuten executive vice president Makoto Arima said in a release.The ebook shop stemmed from a strategic alliance Walmart and Rakuten announced earlier this year, according to the companies.Digital books are available on Kobo eReaders and on applications tailored for mobile devices powered by Apple or Android software.”Working with Kobo enables us to quickly and efficiently launch a full eBook and audiobook catalog on Walmart.com alongside our assortment of physical books,” said Walmart US e-commerce and entertainment general manager Mario Pacini.The move marks the latest effort by Walmart, the former number one US retailer, to counter the rise of Amazon. © 2018 AFP Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Walmart on Wednesday launched a digital book shop in a collaboration with Japanese e-commerce powerhouse Rakuten’s electronic book service Kobo.center_img Walmart, Rakuten unveil alliance on e-books, groceries (Update) Citation: Walmart teams with Rakuten on digital book shop (2018, August 22) retrieved 18 July 2019 from https://phys.org/news/2018-08-walmart-teams-rakuten-digital.html Walmart is taking on Amazon in e-books in partnership with Japanese-based Rakuten Kobolast_img read more


Facebook CEO plans 2019 forums on techs role in society


first_imgFacebook Chief Executive Mark Zuckerberg plans forums in 2019 on the role of technology in society. © 2019 AFP “My challenge for 2019 is to host a series of public discussions about the future of technology in society—the opportunities, the challenges, the hopes and the anxieties,” Zuckerberg wrote on Facebook.The announcement follows a difficult period for the social media company, which has come under fire for its handling of private consumer data and its brass-knuckles approach to company critics, among other issues.Zuckerberg, without directly acknowledging the criticism, said he recognized the need to get out of his comfort zone.”I’m an engineer, and I used to just build out my ideas and hope they’d mostly speak for themselves,” he wrote.”But given the importance of what we do, that doesn’t cut it anymore. So I’m going to put myself out there more than I’ve been comfortable with and engage more in some of these debates about the future, the tradeoffs we face, and where we want to go.”Zuckerberg plans a series of forums that will be broadcast on Facebook, Facebook-owned Instagram or other media.Zuckerberg has made a practice of setting a personal goal each January, such as running 365 miles during the year, or visiting all 50 of the United States.But Zuckerberg’s statement on Tuesday suggested he recognized there was still work to do on the 2018 goal of “fixing” problems at Facebook, such as safeguarding the site from misinformation and propaganda that many experts believe affected the 2016 US presidential election and the Brexit vote in Britain.”Last year, I focused almost all my time on addressing important issues around elections, speech, privacy and well-being,” Zuckerberg wrote.”Facebook is a different company now than it was a couple of years ago because of a much greater focus on these questions. These issues are complex and we will continue focusing on them for years to come.” Citation: Facebook CEO plans 2019 forums on tech’s role in society (2019, January 9) retrieved 17 July 2019 from https://phys.org/news/2019-01-facebook-ceo-forums-tech-role.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.center_img Explore further Facebook Chief Executive Mark Zuckerberg unveiled his personal goal for 2019 on Tuesday: convening a series of public forums on how technology can better serve society. Zuckerberg sees ‘progress’ for Facebook after tumultuous yearlast_img read more


Office Depot and Alibaba opening online store


first_img The two companies announced the agreement Monday as part of a broader array of services they are providing to small business. Over time, the companies intend to help U.S. small businesses sell their products to buyers around the world through Alibaba.com, the wholesale trade site of the Chinese online retail titan the Alibaba Group.It marks Alibaba.com’s first U.S. partnership with a major retailer. The lion’s share of Alibaba Group’s business has been providing retailers and brands in the U.S. and around the globe access to the 700 million Chinese customers through its two major marketplaces Taobao and Tmall.The core of Alibaba.com’s business is connecting small businesses with its more than 150,000 suppliers worldwide, a catalog of product listings and manufacturing capabilities. So Office Depot’s small and medium size business customers will be able to find a broader array of products or a reputable supplier to make their goods in a faster and more effective way. The agreement will give Alibaba access to Office Depot’s 10 million business customers and 1,800 sales agents. Explore further © 2019 The Associated Press. All rights reserved. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Office Depot Inc., based in Boca Raton, Florida, has struggled in recent years with intense competition from Amazon.com, which has been increasingly invading on the office supplier chain’s turf by offering office supply sales for U.S. companies. Office Depot still has 1,350 physical stores. But its new CEO Gerry Smith has been pushing the company to go beyond selling office products to become more of a one-stop shop for businesses for all service at a time when small businesses’ biggest challenges are cash and time. Nearly 70 percent of its Office Depot’s annual sales now come from business customers, up from about 49 percent a few years ago, Office Depot said.That goal of becoming more of one-stop shop for businesses will be furthered under this deal. For example, a toy manufacturer that was buying office supplies from Office Depot could now be steered by Office Depot to Alibaba.com to get access to the most cost-effective producers of toy parts that it’s looking for. It can also help them get quick access to loans.”As a trusted partner to millions of businesses, our customers tell us they want more choice in the market and need an expanded set of products and services to help their businesses grow,” said Smith Office Depot in a statement. “We believe our collaboration with Alibaba.com is exactly what they are asking for.” Home Depot’s online push continues with Company Store buycenter_img Office Depot and Alibaba.com are creating a co-branded online store to expand the reach of both companies with small and medium size businesses. Citation: Office Depot and Alibaba opening online store (2019, March 4) retrieved 17 July 2019 from https://phys.org/news/2019-03-office-depot-alibaba-online.html In this March 17, 2014 file photo, people walk past a company logo at the Alibaba Group headquarters in Hangzhou, in eastern China’s Zhejiang province. Office Depot and Alibaba.com are creating a co-branded online store to expand the reach of both companies with small and medium size businesses. The two companies announced the agreement Monday, March 4, 2019, as part of a broader array of services they are providing to small business. Over time, the companies intend to help U.S. small businesses sell their products to buyers around the world through Alibaba.com. It marks Alibaba.com’s first U.S. partnership with a major company. (Chinatopix via AP, File) This July 12, 2010, file photo shows signage at an Office Depot store in Mountain View, Calif. Office Depot and Alibaba.com are creating a co-branded online store to expand the reach of both companies with small and medium size businesses. The two companies announced the agreement Monday, March 4, 2019, as part of a broader array of services they are providing to small business. Over time, the companies intend to help U.S. small businesses sell their products to buyers around the world through Alibaba.com. It marks Alibaba.com’s first U.S. partnership with a major company. (AP Photo/Paul Sakuma, File)last_img read more


Chewycom hopes to overcome gnawing Wall Street memories


first_img South Florida startups taste the one thing they’ve been missing: money Explore further © 2019 The Associated Press. All rights reserved. Citation: Chewy.com hopes to overcome gnawing Wall Street memories (2019, April 29) retrieved 17 July 2019 from https://phys.org/news/2019-04-petsmart-chewycom.html The Dania Beach, Florida, company is setting out to raise $100 million, but that figure listed in documents filed Monday is likely to change in the weeks ahead as Chewy’s bankers gauge investor demand for the IPO. If all goes according to plan, Chewy’s share will trade under the ticker symbol “CHWY.”It marks the latest IPO in a parade of unprofitable technology companies led by ride-hailing services Uber and Lyft trying to persuade investors that they are mining markets that eventually will turn into money makers.Chewy, which hasn’t been profitable since it was founded in 2011, stands out from the rest of the crowd because of its involvement in online pet sales—a niche that turned into a financial wasteland as hundreds of internet companies imploded after raising billions of dollars during the late 1990s.Pets.com emerged as most prominent of at least nine online pet stores born during that era. It collapsed nearly 19 years ago with the ignominious distinction of leaving behind a sock puppet as its most valuable asset. The puppet, which starred in expensive TV commercials, eventually sold for $125,000 in Pets.com’s liquidation sale and became the mascot for an auto lender providing financing to people with bad credit.Chewy may also have to overcome that specter, given it lost $267.9 million last year on revenue of $3.53 billion.However, much has changed since the days of Pets.com, including how much we pamper our pets. Americans spent $72.6 billion on food, vet visits and other pet related services last year, according to the American Pet Products Association, more than triple the amount spent two decades ago.Chewy will also be able to point to shifts in shopping habits and the evolutionary changes in technology that have made e-commerce a much more viable concept than it was 20 years ago.Millions of consumers now routinely order everything from dog food to diapers online, a trend that has helped establish online retailing pioneer Amazon.com as one of the world’s most valuable companies. But it took Amazon years before it consistently made money.While Amazon’s success could help Chewy woo investors, it also poses potential challenges, too. Amazon also sells pet supplies in its stores and offers free two-day shipping to its more than 100 million households that subscribe to its Prime membership.Chewy thinks it can turn the financial corner by expanding its in-house brands, increasing its pet pharmacy offerings and venturing beyond the U.S. market. The company, which was bought by PetSmart in 2017 for more than $3 billion, operates seven U.S. warehouses where orders are packed and shipped to shoppers.center_img PetSmart’s online pet store Chewy is selling its stock in an initial public offering that may revive memories of the days when its breed of internet retailing seemed like a lost cause. This May 24, 2005, file photo shows a sign of a pet store chain, PetSmart, in Warwick, R.I. PetSmart’s online pet store Chewy is selling its stock in an initial public offering that may revive memories of the days when its breed of internet retailing seemed like a lost cause. The Dania Beach, Florida, company is setting out to raise $100 million, but that figure listed in documents filed Monday, April 29, 2019, is likely to change in the weeks ahead as Chewy’s bankers gauge investor demand for the IPO. (AP Photo/Stew Milne, File) This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more


Uber Eats bows to fans and removes green from Marseille shirt logo


first_img Citation: Uber Eats bows to fans and removes green from Marseille shirt logo (2019, July 3) retrieved 17 July 2019 from https://phys.org/news/2019-07-uber-fans-green-marseille-shirt.html Explore further Uber Eats has changed the colour of the logo that will appear on Marseille shirts next season to placate the club’s fans. © 2019 AFP Uber Eats has grown into Texas’ most-used food delivery appcenter_img In the company logo the word ‘eats’ is green, but that is the colour of one of Marseille’s hated rivals, Saint-Etienne.Fans responded to news of the sponsorship with a campaign on social media and with a banner hanging from a bridge over one of the main streets of the city demanding “no green on our shirts”.”Partner of all those who love OM, Uber Eats will be displayed in black on the jersey,” tweeted the company on Wednesday, with a picture of the club’s jersey with both ‘Uber’ and ‘eats’ in black. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. The green part of Uber Eats’ logo, pictured here on a delivery driver, will be changed on the Marseille team’s jersey after fans complained it was too reminiscent of hated rival Saint-Etiennelast_img read more


EBay beats estimates as more shoppers flock to site shares rise


first_img(Reuters) – EBay Inc (EBAY.O) beat Wall Street estimates for quarterly revenue and profit on Wednesday, as efforts to make its platforms easier to navigate attracted more customers, coupled with growth in its advertising and payments businesses. FILE PHOTO: An eBay sign is seen at an office building in San Jose, California May 28, 2014. REUTERS/Beck DiefenbachThe company’s shares rose nearly 7% to $41.60 in extended trading. EBay, facing intense competition from Amazon.com Inc (AMZN.O) and Walmart Inc (WMT.N), has focused on its promoted listings program and payments business, as well as worked to make its platform simpler to use through the introduction of grouped listings and personal recommendations. More than 940,000 sellers took advantage of the promoted listings, resulting in $89 million of advertising revenue during the quarter, the company said. “The results show eBay’s new revenue sources are working to fuel growth in the bottom-line profitability. The company’s renewed focus on advertising and its new payments business are boosting sales, and that’s enough for investors to get excited,” said Haris Anwar, senior analyst at financial markets platform Investing.com. EBay also said it had reached an agreement with India’s Paytm Mall, owned by Paytm e-commerce, to bring its global inventory onto Paytm’s marketplace. “As part of this collaboration, eBay is making an investment in Paytm Mall for a stake of approximately 5.5%,” Chief Executive Officer Devin Wenig said. EBay forecast third-quarter adjusted profit from continuing operations in the range of 62 cents to 65 cents per share and revenue of $2.61 billion to $2.66 billion. Analysts had expected a profit of 63 cents on revenue of $2.68 billion, according to IBES data from Refinitiv. San Jose, California-based eBay in March announced a review of its StubHub and eBay Classifieds businesses and said it would name two new directors to its board as part of an agreement to ease pressure from activist investors. EBay said active buyers grew 4% to 182 million globally in the reported quarter. However, the company’s gross merchandise volume, which is the value of goods sold on its websites within a certain time frame, fell about 4% to $22.60 billion. The company’s net income from continuing operations fell to $403 million, or 46 cents per share, in the second quarter ended June 30, from $638 million, or 64 cents per share, a year earlier. On an adjusted basis, the company earned 68 cents per share, beating analyst expectations of 62 cents. Revenue rose nearly 2% to $2.69 billion, above estimates of $2.68 billion. Reporting by Akanksha Rana and Arjun Panchadar in Bengaluru; Editing by Bernard Orr and Shounak DasguptaOur Standards:The Thomson Reuters Trust Principles.last_img read more


Tiny Fighting Worms Make One of the Loudest Sounds in the Ocean


first_imgHeadbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Volume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Better Bug Sprays?01:33 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65945-tiny-worms-emit-loud-noise.html?jwsource=cl已复制直播00:0000:3500:35Your Recommended Playlist01:33Better Bug Sprays?01:08Why Do French Fries Taste So Bad When They’re Cold?04:24Sperm Whale Befriends Underwater Robot00:29Robot Jumps Like a Grasshopper, Rolls Like a Ball00:29Video – Giggly Robot02:31Surgical Robotics关闭 Tiny, feisty worms that live off the coast of Japan fight by headbutting each other — and they aren’t quiet about it. During these feuds, the worms emit one of the loudest sounds in the ocean, according to a new study. The source of the underwater hullabaloo is a nearly transparent segmented worm called the Leocratides kimuraorum, which lives inside sponges 279 to 554 feet (85 to 169 meters) deep off the coast of Japan. [The 12 Weirdest Animal Discoveries]Advertisement These wigglies are just a tad more than an inch (29 millimeters) long and have lengthy tentacles and a big mouth (literally). These seemingly quiet creatures revealed their true nature under the spotlight in the lab. A group of researchers used an instrument called a hydrophone to record 15 pops that were emitted from three kimuraorums as they were fighting. In a marine feud researchers dub “mouth-fighting,” the worms approached each other headfirst with their mouths open. During such encounters, the worms’ pharynx muscles expand rapidly, creating a cavitation bubble that collapses and produces a loud “pop” while the worms launch into each other. The researchers found that these pops can reach 157 decibels in the water (which is a different measurement than decibels in the air). From right next to the water tank, the pops sounded like humans snapping their fingers, lead author Goto Ryutaro, an assitant professor at Kyoto University told Live Science. “Though they probably sound louder if you hear them in the water.” The worms are as loud as snapping shrimps, which are one of the biggest noisemakers in the ocean, the authors wrote. What’s more, they found that these worms did not make any noise when simply disturbed, they only did so when they were fighting. They “may use mouth-fighting to defend territory or living chambers from other worms,” the authors wrote July 8 in the journal Current Biology. “A loud pop may be a byproduct of the rapid mouth attack, but it may also aid intraspecific communication.” A loud noise could somehow determine the victor of the fight or even reveal the whereabouts of nearby worms, they wrote. The 10 Strangest Animal Discoveries 13 Extremely Weird Animal Feet Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 minute and see why everyone is addictedVikings: Free Online GameUndoLCR Health SupplementTop Doctor Shares How A Confused Metabolism Affects Your Abdominal FatLCR Health SupplementUndoClassmatesSearch For Any High School Yearbook, It’s Free!ClassmatesUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoUltimate Pet Nutrition Pet SupplementsIf Your Indoor Cat Vomits (Do This Every Day)Ultimate Pet Nutrition Pet SupplementsUndoTruthFinder People Search SubscriptionType in your name and wait 8 seconds. It’s crazy what this site reveals about people.TruthFinder People Search SubscriptionUndo Strange Love: 10 Animals with Truly Weird Courtship Ritualslast_img read more


A Pair of Shipwrecked WWIIEra Submarines Just Vanished from the Sea Near


first_img In Photos: Diving for a Famed Roman Shipwreck Shipwrecks Gallery: Secrets of the Deep Disasters at Sea: 6 Deadliest Shipwrecks More than 100 World War II-era shipwrecks decorate the seafloor around Indonesia, Malaysia and Singapore — and now, there are two fewer. According to Dutch media reports, a pair of submarines that sank off the coast of Malaysia in 1941 mysteriously vanished late last week, leaving behind only some broken scraps and ghostly outlines in the sand. The wrecked subs — Dutch vessels named HNLMS O 16 and HNLMS K XVII — also contained the remains of 79 crewmen, which are now missing. [17 Mysterious Shipwrecks You Can See on Google Earth] How does a shipwreck simply disappear? According to Dutch government officials, the subs were likely stolen by scrap-metal scavengers, who have made a habit of pilfering old wrecks from the region. As many as 40 World War II-era ships have been partially or completely dismantled by scavengers, a 2017 report by the Guardian found, resulting in the desecration of the remains of some 4,500 crewmen who went down with their ships.Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65894-dutch-wwii-era-submarines-vanished.html?jwsource=cl已复制直播00:0000:3500:35  Salvaging a shipwreck usually requires blowing the vessel apart with explosives, then spending days or weeks hauling any valuable metals up onto the surface with a crane. For their trouble, scavengers can come away with millions of dollars’ worth of steel per ransacked ship, plus other spoils, such as copper cables and phosphor bronze propellers, according to the Guardian article. Wartime shipwrecks are protected under international treaties as the unmarked graves of departed soldiers — however, that has not stopped salvagers from destroying the wrecks of the American, British, Dutch, English, Australian and Japanese vessels resting in South East Asian waters. In March 2018, Malaysian officials signed an agreement with the Dutch foreign minister to better protect Dutch war wrecks in Malaysia’s waters. (Parts of Malaysia were once under Dutch colonial rule.) The agreement followed a string of particularly serious shipwreck desecrations; in 2016, the wrecks of three Dutch warships vanished from the bottom of the Java Sea off the coast of Indonesia, along with the remains of 2,200 people, the Guardian reported. Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoSecurity SaversWindows Users Advised To Do This TodaySecurity SaversUndoBeverly Hills MDPlastic Surgeon Tells: “You Can Fill In Wrinkles At Home” (Here’s How)Beverly Hills MDUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndolast_img read more


US tech firms cosy up to China despite trade turmoil


first_imgIntel made 27% of its revenue in China last year, more than in the US or any other market, but it’s fighting to hold on to customers there that it spent decades cultivating. Like many American multinationals with large businesses in the country, Intel is walking a fine line between holding on to that lucrative market and keeping in Washington’s good graces. Neutrality is becoming a tougher stance to maintain.  “There’s been a psychotic break” in what some leaders in the US government want and what American businesses want, said Josh Dorfman, founder of One Thousand Million, a China-focused consultancy and think tank based in Dallas. “Unlike in China, US companies aren’t beholden to the country and are not obligated in any way, shape, or form to be patriotic. They want to make money.”  An Intel spokesman said the company remains engaged with Chinese customers that aren’t on the US’s list of those it sees as a security threat. China is a substantial market for Intel and it has no intention of pulling out now.  Intel isn’t alone. Apple Inc is heavily dependent on China not only for the manufacture of Mac computers and iPhones but it’s also a major consumer market, accounting for about 20% of sales. Even as US President Donald Trump threatened tariffs that would hit Apple products, the California-based company was making plans to shift production of its new Mac Pro computer to China, sending a clear signal of support.  While some companies are considering moving part of their production out of the country, many others are making gestures of goodwill. Walmart Inc last week pledged to invest US$1.2bil (RM4.93bil) in China to upgrade logistics distribution centres. Boeing Co is in negotiations to sell 100 jetliners to Chinese airlines in one of its largest-ever deals, Bloomberg News reported. And last month, 600 US companies and trade groups signed a letter to Trump warning of tariff-related hits to their businesses.  IBM’s Greater China group chairman Liming Chen said that the escalation of China-US trade frictions has created a “confusing environment” for businesses. He outlined International Business Machine Corp’s long relationship with China, dating back to its products first entering the country in the 1920s, and formally establishing a Shanghai office in 1936.  “IBM has participated in the rapid development of China over the past 40 years, while China has also nourished IBM,” he wrote in a post on WeChat in June, calling the country an “indispensable part of our global strategy map”.  The US-China trade war is anchored in competition to dominate the next generation of wireless networks and other technologies as much as politics. The Trump administration worries that American companies in search of profits could actually help China’s tech industry eclipse US prowess in sensitive areas like artificial intelligence and machine learning.  The chairman of the US Joint Chiefs of Staff, Joseph Dunford, lambasted Alphabet Inc in March for Google’s AI work in China, which he alleged “indirectly benefits the Chinese military”. Trump repeated the critique in a subsequent tweet, questioning the Google parent’s loyalties. Google has said it doesn’t work with China’s military.  The same nationalistic fervour is partly behind the US Commerce Department’s May prohibition on selling American components to Chinese telecom behemoth Huawei Technologies Co. Despite Trump’s recent pledge to ease restrictions, Huawei remains on America’s so-called entities list and US firms must apply for special licenses to sell parts to the company.  That hasn’t stopped chipmaker Micron Technology Inc from feverishly trying to find ways to keep supplying the company, one of its largest customers. The US semiconductor industry also lobbied the Trump administration to loosen restrictions on Huawei.  Still, American tech companies are facing a new global reality. They may no longer be able to overlook geopolitics in favour of profits. China may not be the growth saviour it once was.  Tech companies “must now live in a world where their Chinese business partners and global value chains at any given day could blow up”, said James Lewis, director of the tech and public policy program at the Centre for Strategic and International Studies, a Washington think-tank. “Trump might have backed off Huawei for now but next week it could be something different and any of these companies are fair game.”  Lewis, who previously served as the US Commerce Department’s lead for national security and espionage concerns related to high-technology trade with China, said Chinese firms are also racing to become less reliant on the very American firms bending over backwards to keep their business.  Splitting the two economies won’t be easy. Research, development, manufacturing and talent in the US and China are still very much interconnected.  “Innovation by American companies is fuelled by access to the Chinese market,” said Samm Sacks, cybersecurity policy and China digital economy fellow at think tank New America, in Congressional testimony in May.  For Intel’s AI chief, collaboration with China helps the company to build better products and bring new technology to market fast.  “I’m proud of the strong and growing partnership between Intel and Baidu,” Intel’s Rao said in Beijing, after greeting developers with a hearty “nihao”. “By working together to advance AI, Baidu and Intel are helping to usher in a world where AI is ubiquitous.” – Bloomberg Tech News 08 Jul 2019 The Week That Was: A quick tech round-up Related News In a packed ballroom in Beijing’s national convention centre, the executive from a major technology company laid out ambitious plans for the future of artificial intelligence in China. He explained how customised semiconductors would help power everything from autonomous cars to voice-activated industrial machines.  Only this wasn’t a state-backed enterprise. This was Intel Corp, the largest US chipmaker.  The company’s AI chief, Naveen Rao, pledged to work closely, “engineer to engineer”, on cutting-edge technology with the 7,000 people that attended Baidu Inc’s annual developers conference last week. Intel was the top sponsor of the event.  Rao made no mention of politics, though his overwhelming support of Baidu, a Chinese national tech champion, sent a powerful message: Even as US and Chinese leaders are locked in a fierce battle over technological supremacy, companies like Intel remain big backers of China’s tech industry because they rely on the country for significant contributions of revenue, production chains and even talent.  Related News Culture 18h ago Of Nostalgia And Emotional Ties To Stuff {{category}} {{time}} {{title}} Even as US and Chinese leaders are locked in a fierce battle over technological supremacy, companies like Intel remain big backers of China’s tech industry because they rely on the country for significant contributions of revenue, production chains and even talent. — Bloomberg Tech News 10 Jul 2019 Apple starts China app development programme in services business pushlast_img read more


Safety action plan activated for Sarawak villages on interstate gaspipe route


first_imgSarawak Fire and Rescue Department activates safety action plan for villagers along Sarawak to Sabah gas pipe route in Long Laput today. {{category}} {{time}} {{title}} MIRI: The Sarawak Fire and Rescue Department has activated a safety action plan for villagers living along the Sarawak-Sabah interstate gas-pipe route in Sarawak.Under the action plan launched in Long Laput in Ulu Baram district in northern Sarawak, these villagers will be trained to deal with any possible fire explosion incidents.Sarawak Fire and Rescue Department is also commissioning 13 voluntary community Bomba squads in Long Laput, Long Bemang and Uma Akeh which are located along the gas-pipeline route.Petronas is helping to sponsor firefighting equipment for these squads. Sarawak fire chief Khirudin Drahman launched the action plan and the voluntary Bomba units on Friday (July 12) morning in Long Laput village.The ceremony was witnessed by community leaders and Petronas pipeline operation manager Suffian Sabeli and Miri fire chief Supt Law Poh Kiong.Khirudin said the safety of the people living along the 600km-long pipeline route was a top priority.”The action plan involves training the villagers to be well-equipped and fully trained to handle any emergency situations if any incident happens along the gas pipeline.”Every settlement along the route will see this action plan activated,” he said.On Jan 10 last year, there was an eruption along the section of the giant pipeline near the Long Luping settlement located adjacent the Sarawak-Sabah border. That was the second incident to happen in four years in the northern Sarawak side.Petronas carried out a thorough inspection of the pipes after the incident.After Long Luping, other settlements include Long Semadoh and Long Sukang and then the Lawas hinterland, where the pipes connect to the Baram side, then winds towards Miri and Bintulu.The pipeline is to channel gas from Kimanis in interior Sabah to Bintulu port in northern Sarawak for processing and export.The pipeline is a RM4bil project by Petronas which started about 10 years ago.On June 11, 2014, an explosion occurred in the hills of Lawas district when a leak happened at a section of the pipeline.No one was injured in that 2014 incident. Nation 08 May 2019 Fire at Sabah-Sarawak gas pipeline, no explosion or casualties reported Related News Related News Nation 17 Apr 2019 Sarawak Bomba flooding forest to contain fire in Kuala Baram Nation 11 Jul 2019 Three early morning fires break out three hours apart in northern Sarawaklast_img read more


Leave PLUS alone


first_img Tags / Keywords: Related News As a concession holder, PLUS generates revenue from mostly toll collection and after paying for running expenses and interest on its debts, its free cash flow is mainly used for dividends. Based on audited 2017 figures, PLUS generated some RM3.8bil in revenue and it is a strong cash cow for its shareholders, generating some RM2.6bil in operating cash flows.After the payment of capex and repayment of debts, it had about RM0.8bil in free cash flows for distribution as dividends to shareholders. However, for 2017, PLUS reported a pre-tax loss and net loss, as its bottom-line was impacted by the amortisation cost of the concession acquired in 2012 as a non-cash item. This one-line item alone results in a charge of about RM1.1bil to its income statement in 2017. Despite paying RM690mil in dividends to its shareholders, PLUS’ cash reserves remained strong and in excess of RM3.3bil as at end of 2017. Majority of consumers do benefit from the dividends that are paid by PLUS to its shareholders. EPF and UEM Group, whose actual owners are all of us – members of the EPF and all Malaysians via the government’s ownerships of Khazanah Nasional. For EPF, dividends received from PLUS makes up its investment income, which is than distributed to members as dividends, while for the government, the dividends received from Khazanah is deployed for operating and development expenditure. Should PLUS be sold? The Pakatan Harapan’s promise in its manifesto in the 14th general election (GE14) was to abolish tolls and it intends to review all toll agreements and renegotiate to derive best value for money for the consumers with the ultimate aim of abolishing tolls gradually. The recent proposed acquisition of the four urban toll highways is a testament to the government’s commitment of not only ensuring no more toll hikes but for consumers to enjoy lower toll rates during off-peak hours and this will cease upon the expiry of the current concession periods for the four highways. It is believed that Maju Holdings, who had earlier attempted to acquire PLUS for RM36bil in 2017, is now knocking on the door for the second time. It’s proposal, according to a financial weekly, although entails a reduction in toll rates, calls for a longer concession period of between 10 and 30 years from the current concession period that ends in 2038. In addition, the toll reduction is said to be carried out over a six-year period while the highways would be fully lit up at a cost of RM5.3bil.The proposal also entails the government maintaining its debt guarantee throughout the concession period and the extended period as well. Based on PLUS’ 2017 audited accounts and Malaysian Rating Corp Bhd’s (MARC) rating report, out of the RM30.2bil PLUS’ debt papers, RM11bil are government guaranteed while the balance RM19.2bil papers are rated “AAA” by MARC. Should PLUS be sold to Maju Holdings? What does it mean in the context of Pakatan’s manifesto and its promises? Indeed, the proposal is seen as detrimental to all Malaysians as the proposal requires the government to maintain its debt guarantee for not only the concession period but for the extended period as well. Question is, will the potential new shareholder be able to raise the RM30.2bil bonds based on its own credit profile and reputation in the capital market without seeking the government’s additional support to provide 100% guarantee on the debt papers?Ironically, there was a rating downgrade on Maju Holdings’ wholly-owned subsidiary, Bright Focus Bhd’s (BFB) RM1.35bil sukuk papers from “A1” to “BB1” and at the same time placed on negative watch early last month by Rating Agency Malaysia (RAM). The rating agency further highlighted that the downgrade is based on the severe impairment in BFB’s debt-servicing metrics following further unanticipated advances by its 96.8%-held subsidiary, Maju Expressway SB, to the ultimate parent company Maju Holdings, in addition to a deterioration in Maju Expressway Sdn Bhd’s (MEX) projected annual cash flow. Based on RAM’s rating rationale, an entity rated “BB” has a weak capacity to meet its financial obligations and highly vulnerable to adverse changes in circumstances, economic conditions and/or operating environments. By the way, when a company’s paper is downgraded to “BB” level, most investors will shy away from the exposure to these papers as “BB” is deemed to be non-investment grade. Operationally, while Maju Holdings has the experience in running MEX, it’s 26 km dual carriageway, it is a pale shadow to PLUS’ massive 1,1070.5 km network. What PLUS invests in its highway network, inclusive of the massive rest areas, widening of roads and maintenance for an aged highway, is not the same as the relatively new kid on the block. Hence PLUS’ maintenance cost can be much higher than MEX, when measured on a per kilometre basis. The fact that the government has taken steps to nationalise privately-held assets via the proposed acquisition of the four urban toll operators and proposed reduction in toll rates without extending the respective concession periods suggests that selling PLUS to Maju Holdings will be in contradiction of the government’s intention to reduce the cost of living and abolishment of tolls in time to come. Should the government plan to nationalise the 49% not already owned, it should be discussing with the EPF to acquire the stake. Engaging Maju Holdings for the disposal of the 51% stake, whose main purpose is seen as free cash flow generation for an extended period of time, and on top of having the government to possibly take on higher debt guarantee, defeats the objective of Pakatan’s manifesto and its promises to the people. Worse, what if Maju Holdings uses these strong free cash flows to its parent company as advances, like how Maju Expressway has done so and as highlighted by RAM? But, if the reason why we are seeing fresh bids on PLUS is due to its attractive and recurring strong cash flow, any potential investor would have to be an investor with deep pockets and has the ability to raise the necessary funds to acquire PLUS on a willing buyer-willing seller basis and without the government having to provide any guarantee whatsoever. In conclusion, selling PLUS to Maju Holdings is not the solution to fulfil Pakatan’s election manifesto neither for the benefit of the people. After all, just two days ago, the Finance Ministry made a preliminary decision to oppose the takeover of PLUS by Maju Holdings after considering the views from Khazanah and the EPF. In addition, the government should not be selling a company with a “AAA” rating to another corporate which has a “BB1” market rating and worse, below investment grade. Just leave PLUS alone.The views expressed by the writer is solely that of his own. Nation 11 Jul 2019 Finance Ministry makes preliminary objection to PLUS Malaysia takeover Nation 09 Jul 2019 LGE: Proposed takeover of four highways will see motorists paying less for toll Corporate News 2d ago Legal suit pending sukuk revampcenter_img PLUS Malaysia Bhd is a national asset owned by all Malaysians via UEM Group Bhd’s 51% stake in the company, which in turn is wholly-owned by Khazanah Nasional, the government’s sovereign wealth fund. The Employees Provident Fund (EPF) is the other 49% shareholder in PLUS and as the EPF has more than 14 million members, these members are indirect owners of PLUS too. Both UEM and EPF completed the acquisition of PLUS for a staggering RM23bil in cash in January 2012. Today, PLUS owns several concessions and they include the North-South Expressway, the New Klang Valley Expressway, the Federal Highway Route 2, the Seremban-Port Dickson Highway, the North-South Expressway Central Link, the Malaysia-Singapore Second Crossing, the Butterworth-Kulim Expressway, the Penang Bridge and Lebuhraya Pantai Timur 2 (LPT2). All in, PLUS owns a total length of 1,170.5 km and with the exception of LPT2 concession, which expires in 2034, all other concessions expire in December 2038 – a little over 19 years from now. Ever since PLUS was taken private in 2012 by the government and the EPF, there have been numerous attempts to buy it over from the present shareholders by several individuals via their respective vehicles and in return, providing “sweet deal” to not only the current shareholders but to highway users in the form of a freeze in toll rate hikes, potential discounted toll rates but with extended concession periods. Related News Corporate News , Comment , Pankaj C Kumar {{category}} {{time}} {{title}}last_img read more


Mumbai 12yearold boy drowns in pit at Worli Sea Link


first_img India Today Web Desk New DelhiJuly 13, 2019UPDATED: July 13, 2019 20:12 IST A 12-year-old boy drowned in a pit in Mumbai, Maharashtra | Photo from ANIHIGHLIGHTSThe pit was dug for Coastal Road Project at Coastal RoadThe boy was rushed to a nearby hospital after the incidentThe boy was declared dead by the hospitalA 12-year-old boy in Mumbai drowned in a pit on Saturday.The 12-year-old boy drowned in the pit dug for a Coastal Road Project at Coastal Road, Worli Sea Link.The boy was admitted to a nearby hospital by locals but he was declared brought dead.Earlier in the week, heavy rainfall in Mumbai led to the temporary suspension of activity at the Chhatrapati Shivaji Maharaj International Airport.Large parts of the city and suburbs, besides Palghar, Thane and Raigad, were lashed with heavy rain since this week.As Mumbai started the week on a flooded note, a roof collapsed in Shivaji Nagar in Govandi. Eight people were injured in the incident.According to the Indian Meteorological Department, Mumbai will experience intermittent rain or showers with heavy falls at isolated places.Also Read | Mumbai’s Tulsi lake overflows due to heavy rainsAlso Read | Mumbai: Unable to locate 3-year-old Divyansh who fell into gutter, search teams call off operationsAlso Watch | Did this scooter fall into a rain-filled pothole’ in Mumbai?For the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byMohak Gupta Tags :Follow MumbaiFollow Worli Sea Link Mumbai: 12-year-old boy drowns in pit at Worli Sea LinkThe boy was admitted to a nearby hospital by locals but he was declared brought dead.advertisement Nextlast_img read more


First Rafale jet to IAF will be delivered in September as per


first_imgFirst Rafale jet to IAF will be delivered in September as per schedule, says top govt officialRafale fighter jets, manufactured by France-based Dassault Aviation, are twin-engine multi-role fighter aircraft. These are nuclear capable and can engage in both air-to-air and air-to-ground attacks.advertisement Press Trust of India KolkataJuly 13, 2019UPDATED: July 13, 2019 18:49 IST All the 36 Rafale jets will be delivered to the Indian Air Force within the next two years, French Ambassador to India, Alexandre Ziegler said.The first Rafale fighter jet will be delivered to the Indian Air Force in September 2019 as per schedule, a top government official said on Saturday.Rafale fighter jets, manufactured by France-based Dassault Aviation, are twin-engine multi-role fighter aircraft. These are nuclear capable and can engage in both air-to-air and air-to-ground attacks.The first Rafale fighter jet will be delivered in September, Ajay Kumar, secretary to the department of defence production, said.French Ambassador to India, Alexandre Ziegler had, earlier this month, assured that the first Rafale fighter aircraft will be delivered within two months and will be “perfectly on time”.All the 36 Rafale jets will be delivered to the Indian Air Force within the next two years, he said.The Rafale deal has drawn flak from the Opposition which has alleged widespread corruption in the contract.Asked about the Rafale offset partner issue, Kumar said, “It will be done as per the rules.”He was speaking on the sidelines of the inauguration of Bharat Chamber Defence Facilitation Centre in Kolkata.ALSO READ | First Rafale jet to be delivered in 2 months: French Ambassador ALSO WATCH | Air Marshal RKS Bhadauria shares his experience of flying a Rafale jetFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySnigdha Choudhury Nextlast_img read more


Mumbais Tulsi lake overflows due to heavy rains


first_img Vidya MumbaiJuly 13, 2019UPDATED: July 13, 2019 00:15 IST Mumbai’s Tulsi lake overflowed at 7 pm on Friday. (Photo: ANI)Mumbai’s Tulsi lake overflowed at 7 pm on Friday due to incessant rains. Last year, the monsoon arrived late and the lake filled to its capacity on July 9.This year, the rainfall in the catchment areas was higher and the lake overflowed.Brihanmumbai Municipal Corporation (BMC) Chief Public Relations Officer (CPRO) said, “One of Mumbai’s sources of water supply, lake Tulsi started overflowing, today.”Tulsi is the smallest lake which has a share of 1 per cent in the total water supply. The other one is Vihar Lake. Both of the lakes are located in Sanjay Gandhi National Park (SGNP).Meanwhile, water quantum in lakes supplying to Mumbai’s needs rose further touching almost as much as last year’s water stocks the same day.The total water stocks on Friday was 6.35 lakh million litre or 43.92% of the required stocks.Last year on July 12, the total water stocks stood at 6.36 lakh million litre or 44 per cent of the required quantum, according to Times of India.There was a significant rise in water stocks as compared to a day earlier as well. On Thursday, the total water quantum stood at 5.47 lakh million litre or 37.83 per cent.The total required water stocks in all the seven lakes is 14.47 lakh million litres.Also Read | Mumbai rains: Flight operations briefly suspended at Chhatrapati Shivaji airport due to low visibilityAlso Watch | Mumbai rains: Is City of Dreams now Ram bharose?For the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byShifa Naseer Tags :Follow Mumbai rainsFollow Tulsi lake Next Mumbai’s Tulsi lake overflows due to heavy rainsTulsi is the smallest lake which has a share of 1 per cent in the total water supply. The other one is Vihar Lake.advertisementlast_img read more