Tag: 苏州夜生活桑拿海选

Patrick Gildea Hairdressing win RSVP’s Best Salon in Ulster

first_imgPatrick Gildea Hairdressing, Centre of Excellence have been presented with another prestigious award – Best Salon In Ulster by RSVP Magazine.This talented team led by Irish Hairdressing Federation Icon, Patrick, are thrilled to be successful in this award for the 5th time!Commenting on the success Patrick said “We have had an amazing week, bringing home two trophies from the IHF Championships, receiving Best Salon in Ulster from RSVP Magazine and being nominated for Best Salon in Ireland. “It is great that our focus on delivering the best hairdressing experience in Ireland is being recognised. We have a great team who are passionate about continuous self-development and continuously push themselves to be the very best they can be.“We would love to win Best Salon In Ireland this year again – but we need your votes; please vote for us.”You can vote for the team here https://www.rsvplive.ie/style/vote-irelands-best-hair-salon-16026656RSVP Magazine said “This salon delivers something special- you couldn’t be in safer hands form their talented team of 30.” For more information on Patrick Gildea Hairdressing see http://www.patrickgildea.ie or http://www.facebook.com/patrickgildeahairdressing. To vote for them please as best salon in Ireland click here https://www.rsvplive.ie/style/vote-irelands-best-hair-salon-16026656Patrick Gildea Hairdressing win RSVP’s Best Salon in Ulster was last modified: May 27th, 2019 by Staff WriterShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:hairdressingmagazinePatrick GildeaRSVPlast_img read more

Mere Biochemistry: Cell Division Involves Thousands of Complex, Interacting Parts

first_imgIn biochemistry, the stem -mere means “part” (as in centromere, telomere) and -some means “body” (as in chromosome, ribosome).  Biochemists are learning that these cell organelles are not -mere bit parts, but -some fit bodies.Telomeres and chromosomes:  PhysOrg reported that the chemical “caps” on the end of chromosomes, called telomeres, have a special code to keep them intact.  Scientists from Portugal and U of Indiana found that a histone tag near the telomeres keeps the DNA Damage team from tying separate chromosomes together – a response that would spell death for the cell.  “It’s amazing,” a Portuguese scientist remarked, “but it appears to be this single change that underlies the cell’s ability to distinguish the end of the chromosome (i.e. a telomere) from a break in the middle.”  Described as “like the plastic caps on shoelaces,” telomeres not only keep chromosomes intact, but are also implicated in the aging process as they wear off, or in cancer when they go awry.Ribosome quality control:  Cells need to search and destroy nascent proteins that fail to have a “stop code” when being translated in the ribosome.  PhysOrg reported that a quality control mechanism in bacteria that corrects or deletes failed polypeptides in the ribosomes operates similarly, but is unrelated to, the system in eukaryotes.  Scientists at the Scripps Research Institute used a “homology approach” to identify a protein in yeast that performs the same inspection role on nascent proteins that a different protein plays in bacteria.  “The [bacterial and eukaryotic] mechanisms are very different, but the concepts are remarkably similar,” one researcher said.  “—that’s the beauty of it.”  We know all about that.  Search engines are a concept, but the manifestations (Google, Bing) can be very different.Centromere code:  It goes without saying that heredity depends on accurate copying of DNA at each cell division.  PhysOrg reported on a finding at Pennsylvania School of Medicine that showed how the “histone code” epigenetically (i.e., apart from DNA inheritance) identifies the center of each chromosome – the centromere – so that the spindle apparatus accurately connects to it during cell division (see also 05/06/2010 and 12/17/2007).  Science Daily described how a “centromere identifier attracts other proteins, and in cell division builds a massive structure, the kinetochore, for pulling the duplicated chromosomes apart during cell division.”  The article quoted a researcher happily saying, “Our work gives us the first high-resolution view of the molecules that control genetic inheritance at cell division.  This is a big step forward in a puzzle that biologists have been chipping away at for over 150 years.”Telomere linemen:  Researchers at the Wistar Institute identified another key player in the cell’s task of keeping its chromosome ends (telomeres) intact.  A two-part protein named Cdc13, which has a “crucial support role in maintaining and lengthening telomeres,” is able to simultaneously grip the tail end of the telomere while recruiting the telomerase enzyme to add more cap units.  Emmanuel Skordalakes of Wistar had an interesting analogy to describe the action: “You can think of Cdc13 as if it were you hanging on to the edge of a cliff, with one grip stronger than the other,” he said.  “You’re going to keep that strong hand on the cliff’s edge while your weaker hand reaches into your pocket for your phone.”Centrosomes untangled:  Centromeres, centrosomes; what’s the difference?  Centromeres are the center parts of chromosomes where attachments are made to pull paired chromosomes apart during cell division.  The centrosome is also involved in cell division, but it is a “complex made up of several hundred different proteins,” reported Science Daily, that includes the centrioles and the spindle apparatus that winches the paired chromosomes apart.  In attempting to dissect differences between normal divisions and faulty ones, German biochemists investigating centrosomes in fruit flies “identified more than 250 different proteins making up this complex…. They found a whole series of proteins responsible for the separation of chromosomes, number of centrosomes and their structure.”  They hope their detective work will “unravel regulatory networks in the future, which will help to target and interfere with the division of cancer cells.”Switched-on mitosis:  A casual look at cells in identical circumstances seems to show them dividing at random.  Some scientists have preferred to think there is something inherent in a cell that tells it when to divide.  There is: a toggle switch.  Scientists at Duke University found a switch in the cell that determines which cells will divide, and which ones won’t.  PhysOrg said this “gene circuit” acts like a “bistable switch.”  The article explained, “The gene circuit is in all cells and can tell identical cells to live in two states simultaneously, either on or off.”  When the signal to divide comes, some respond, and some don’t.  This helps reconcile competing hypotheses about how cells know when it’s time to divide.  “Bistability is not unique to biology,” the article said.  In electrical engineering, for example, bistability describes the functioning of a toggle switch, a hinged switch that can assume either one of two positions – on or off.”  The bistable switch in the cell determines which cells will be the dividers and which will not.  “Genetic switch underlies noisy cell division” was PhysOrg’s headline.Coded chromosomes:  Cell division is like a symphony, reported Science Daily, describing what researchers at Rockefeller University have found.  They found hard evidence for the “histone code hypothesis,” the idea that tags on the histone proteins on which DNA is wound provide an independent epigenetic code, distinct from the DNA code, that affects heredity (for historical background, see 11/04/2002, 02/16/2004 and 07/26/2006).   “The orchestration of the exact timing and localization of the vast array of molecules and processes involved in reproducing the chromosomes is one of the basic wonders of biology and is at the core of both healthy living and diseases such as cancer, that arise when the process goes awry,” the article said.  “We cracked one code,” Hironori Funabiki, head of the Laboratory of Chromosome and Cell Biology at Rockefeller, said, “but there are yet many to be decoded to understand how chromosomes orchestrate mitosis.”PhysOrg reported that scientists at the University of Edinburgh “were able to define some 4,000 proteins involved in the division of cells.”  These proteins “protect the fragile genetic material and help it fold into the correct shape before it splits into two new cells.”  They were astonished at “the intricacies of this process” but had nothing to say about evolution.This is some of the de facto intelligent design research taking place around the world.  Keep pouring on the evidence: nothing in biology makes sense in the darkness of evolution; nothing in biology makes sense except in the light of intelligent design.(Visited 49 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

Meet Bafana’s number-one fan

first_imgSaddam loves Bafana Bafana and his vuvuzela. International journalists find him an interesting fan to interview (Images: Bongani Nkosi) MEDIA CONTACTS • Freddie “Saddam” Maake Football fan and musician +27 82 950 7619 RELATED ARTICLES • World Cup world record for SA fan • Bafana go out with pride intact • Black Stars shine for Africa • The vuvuzela: Bafana’s 12th man • Bafana frenzy grips the nation • The master of the makarapaBongani NkosiMost South Africans love Bafana Bafana, the national football team, but some love it more than others – and are always ready to go to daunting heights for it.Freddie “Saddam” Maake is one of those fanatics who gives his all when it comes to supporting Bafana. In victory or defeat, Maake is always behind the team, using his trademark vuvuzela trumpet to inspire other fans to show the same spirit.“I always tell supporters they must not boo Bafana when they’re not playing well,” he said when I met him at his home in Tembisa, a township east of Johannesburg. “It hurts the players. The players must always be strong.“I like to be a technical advisor to supporters. I encourage them to travel with the team,” he added.Maake’s dining room is laden with football memorabilia, ranging from makarapas, vuvuzelas, supporter awards and photographs of him with top players. “This is my museum,” he said.This unyielding passion for Bafana, the 55-year-old father of nine recalls, was ignited in 1992 when South African sport was reincorporated into the international arena after years of isolation. Initially he was part of the almost 42 000-strong crowd who showed up to support the match between South Africa and Zimbabwe on 16 August of that year.“I travelled with Bafana Bafana to Zimbabwe in 1992, and from there the show went on,” he said. “I remember we lost that game 4-1.”A football stadium is never dull when Maake and his friends are in the stands. Rest assured that when they’re there, the fan zone becomes a hotbed of vibrancy: they wear comical outfits to grab attention and loud toots ooze from their vuvuzelas. They also sing and dance to get the atmosphere going.One of Maake’s friends, David Mabu, describes their style of support as a fusion of African and European subcultures. “We’re unique, as we mix African and European energy.”Bafana’s top fanMaake can be seen as one of the “godfathers” of the type of stadium atmosphere that’s experienced nowadays during local and international football games played in the country, having followed Bafana since the 1990s.“We were very excited at the stadiums in 1996,” he said, referring to Bafana’s winning of the Africa Cup of Nations in that year.It was in 1997 that he was first recognised as being the number-one follower of local football, winning a national award for “supporter of the year”.South Africa’s first participation in the Fifa World Cup in 1998 in France brings back great memories for Maake. “I won a trip to the World Cup for being a number-one supporter,” he said.He’s also been to many of the Africa Cup of Nation (Afcon) tournaments, he said. “We have travelled to most of the Afcons. I remember in 2001 we went to Mali.”The 2002 Fifa World Cup in Korea and Japan was also a highlight for him – as was the following Cup in Germany in 2006. Although South Africa didn’t qualify for this, Maake said the South African Football Association (Safa) sponsored his trip to attend. “Safa sent me there to represent South Africa, to fly our flag.”According to Maake, Safa has sponsored most of his trips and tickets to games in recognition of his efforts. “Safa has really been supportive to me.”As an official supporter, he’s been to more than 20 countries – including Denmark, Egypt and Swaziland – and always takes along a vuvuzela, an instrument he claims to have invented, to cheer Bafana on.Awards recognising his passion keep coming through: most recently, in March, he jetted off to Ghana with a Safa official to collect an accolade for being such an enthusiastic fan.‘I’m a football slave’Also an ardent fan of the local Kaizer Chiefs team, Maake practically lives for football. “I live soccer. I drink soccer … I’m a soccer slave,” he said.“If you say ‘let’s go to the stadium’, I’ll take my vuvuzela and go there.”Although his fanaticism started in the 1990s, Maake said he has been a fan of football since 1965, and has even lost a few jobs owing to his obsession with stadiums and the sport. Nowadays he earns a living from selling his music album, Vuvuzela Saddam Maake Volume 2, released this year, and vuvuzelas. He trades from his house and stadiums.2010 Fifa World CupMaake has already been to 12 of the matches, including all three Bafana games, and has drawn a number of tourists to his home since the kick-off earlier this month.Although disappointed that South Africa has been knocked out, he’s still enjoying the tournament. “I was hoping to attend 20 matches, at least,” he said. He’s now supporting Ghana and Brazil.Always positive about the sport in South Africa and Bafana’s future, Maake said he’s consoled by the fact that the country is hosting the “best World Cup” ever, and that it will leave a lasting legacy.“It’s not the field of play that matters … this is the best World Cup you’ll ever see. One team will win, but the stadiums are ours. Beyond 2010 we’ll [continue to] use these stadiums,” he said.last_img read more

Should I Build a Mechanical Room in My Attic?

first_imgIn many southern states, it’s common for an HVAC contractor to install an air handler and ductwork in a vented unconditioned attic. In July, the attic temperature rises to 120°F. Perhaps the homeowner, irritated by his hot bedroom and concerned about his high electricity bills, sticks his head through the attic access hatch, and nearly faints. It’s a sauna up there.One solution to this problem is to convert the vented unconditioned attic to an unvented conditioned attic by applying spray foam to the underside of the roof sheathing. That’s a good solution, because it brings the attic air handler and attic ductwork into the home’s conditioned space, but the price tag is very high.So the homeowner thinks of a different solution, and posts a question on GBA: Can I build a mechanical room with insulated walls in my attic, so that the air handler is (more or less) in conditioned space?I usually advise, “That’s a bad idea.” Let’s investigate why. The many features of a mechanical room First of all, let’s describe the features of an adequate mechanical room. It needs to have an insulated floor, walls, and ceiling, and these assemblies need to be relatively airtight. The walls should be finished with 5/8-inch drywall. The room needs to be big enough to allow maintenance workers to access the equipment comfortably, and to swap failed equipment with new equipment when necessary.Can you create this type of mechanical room in an attic? Sometimes, but not always. What are the hurdles?Let’s say you’ve addressed these hurdles. Your attic has a generously sized access hatch, and you don’t have any furnaces or water heaters up there — just an air handler… Sign up for a free trial and get instant access to this article as well as GBA’s complete library of premium articles and construction details. Start Free Trial Already a member? Log incenter_img This article is only available to GBA Prime Memberslast_img read more