Rabat – Personal Envoy of the United Nations Secretary-General Horst Kohler held talks on Tuesday with Russian Minister of Foreign Affairs Sergey Lavrov on the Western Sahara and Polisario.A statement from the Russian Ministry of Foreign Affairs noted that, during the meeting, the two officials stressed, “There are no alternatives to a political settlement of the Western Sahara dispute in line with relevant UN Security Council resolutions.”Kohler and Lavrov also emphasized the need for the development of a mutually acceptable solution to end the conflict to “promote the general improvement of the situation in North Africa.” In the meeting, the Russian minister expressed his country’s full support for the efforts conducted by UNSG Antonio Guterres, the UNSG personal envoy, and the United Nations Mission in the territory, known as MINURSO, with “its key role in maintaining regional stability.”Kohler also met with the Russian Deputy Foreign Minister and Special Presidential Representative for the Middle East and Africa, Mikhail Bogdanov, on “the full range of issues” related to the Western Sahara settlement process.Though there was no explicit mention of the subject, the timing of the meeting indicates that key discussion topics likely included Polisario’s recent incursions into the area east Morocco’s defense wall in the Western Sahara and Morocco’s corresponding threat of military force to prevent any change of the status quo.Earlier this month, Morocco informed the Security Council that it will consider any Polisario’s attempt to change the status quo of the region as “casus belli” (cause of war) and would resort to all available means, including the use of military force, as prevention.Regional media reported last week that Morocco had informed Algeria, via a European diplomat, that it was prepping to take military action against the Polisario. A report published by Moroccan news outlet Assabah on Thursday claimed that France allegedly informed Algeria that it would not oppose limited military strikes by Morocco against the Polisario.Kohler Attempts to Preserve the Political ProcessThe timing of Kohler’s meeting with Russian officials–just less than three weeks before the Security Council is due to renew MINURSO’s mandate for one year–might signal that he is seeking Russia’s help in persuading Morocco to take the military option off the table.Kohler has held several meetings with international officials, including African Union and European Union representatives. In January, Kohler held talks about the conflict with AU Commission Chairperson Moussa Faki Mahamat in Addis Ababa.The UNSG Envoy also met with Rwanda’s President, Paul Kagame, who is also the president of the African Union. Kohler’s meetings with the African leaders followed his official meeting with the EU’s High Representative Federica Mogherini, on January 9, in Brussels.Recently, the UNSG and his personal envoy, reassured Morocco that the UN is the only body that has the legitimacy “to lead the political process” to reach a consensual solution in the Western Sahara conflict.
AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email A whirlwind of discussion about renewables happened Monday night in CalgaryAn open house at the University of Calgary gathered experts and everyday Albertans for feedback about energy efficiency.Panel Leader Dr. David Wheeler says they want to make sure Albertans see benefits in the short term.“I’m beginning to learn how much people are committed in this province to energy efficiency and renewables, and I do believe with the right leadership and design, the new Energy Efficiency Agency for Alberta will become a national leader in relatively short order, certainly within a matter of a few years,” he said.A second open house happens Wednesday in Edmonton.The panel will also be meeting with education groups, First Nations leaders, and Metis leaders in the next few months. Energy Efficiency Advisory Panel hears from Calgarians by 660 NEWS Staff Posted Jul 19, 2016 7:01 am MDT
by Martin Crutsinger, The Associated Press Posted Mar 6, 2017 8:19 am MDT Last Updated Mar 6, 2017 at 2:20 pm MDT AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email US factory orders up 1.2 per cent in January WASHINGTON – U.S. businesses increased their orders in January, although a key component that tracks business investment spending fell for the first time in four months.Factory orders rose 1.2 per cent, led by a jump in demand for aircraft, the Commerce Department reported Monday. Orders had risen 1.3 per cent in December.A category that serves as a proxy for business investment edged down 0.1 per cent in January after three months of solid gains. It was the first setback since a 1.5 per cent decline in the category in September.American manufacturing has been under stress for nearly two years as a strong dollar cut into export sales and a big plunge in oil prices triggered cutbacks by energy companies. Manufacturers are expected to see stronger sales in 2017.Demand for durable goods, items ranging from bicycles to battleships that are expected to last at least three years, rose 2 per cent. That was even better than the initial estimate of a 1.8 per cent gain made in an advance report on Feb. 27. Demand for nondurable goods, everything from paper products to chemicals and food, rose 0.4 per cent in January after a 3.4 per cent jump in December.The strength in January reflected a surge in orders for commercial aircraft, which jumped 69.8 per cent, and a 62.2 0ercent rise in orders for military aircraft. Demand for motor vehicles and parts rose 0.8 per cent, while orders for ships and boats fell 33.7 per cent.Orders for machinery rose 0.9 per cent. Demand for primary metals such as iron, steel and aluminum fell 1.5 per cent.Manufacturing firms have struggled since 2015 with a rising value of the dollar, which makes exports more expensive in foreign markets, and a plunge in oil prices which triggered big reductions in investment by U.S. energy companies.But economists are hopeful that energy investment will begin rising now that oil prices are rebounding, and they believe export demand should also improve now that the dollar has stabilized.
“Rather, it seems that lower demand and increased law enforcement has sparked brutal turf wars between traffickers as they fight over a share in a reduced market,” the report says.In Mexico, the implementation of a security strategy in 2006 seeking to disrupt the northbound supply of cocaine triggered conflict over new “plazas” at key border crossings, notably along the Guatemalan/Honduran border.The study points out that flows of drug trafficking have become concentrated in the countries least capable of dealing with them, and emphasizes that it is essential to tackle impunity and corruption, while building police and criminal justice capacity. The report will be discussed at a high-level presentation to ministers and ambassadors from the Central American region tomorrow in New York on the margins of the 67th session of the General Assembly. The study, “Transnational Organized Crime in Central America and the Caribbean: A Threat Assessment,” examines various aspects of the impact of the major trafficking flows of cocaine, and fire arms as well as the sex trade and migrant smuggling in the region.The report, produced by the UN Office on Drugs and Crime (UNODC), argues that even if the northbound cocaine flows dwindle, criminal groups would vie for profits from other highly lucrative illicit activities and continue to spread mayhem. “The relationship between development, the rule of law and security needs to be fully understood,” said UNODC Executive Director Yury Fedotov. “Drugs and crime are also development issues, while stability can be promoted by embracing human rights and access to justice.”According to UNODC, Central America has some of the highest homicide rates in the world, with 39 murders per 100,000 citizens in Guatemala, 69 per 100,000 in El Salvador and 92 per 100,000 in Honduras in 2011. Wedged between the suppliers of coca in the south and the consumers of cocaine in the north, the region has become a transit corridor. However, the high rates of violence are not always associated with drug trafficking, UNODC said in a news release. El Salvador, for example, has a relatively low cocaine flow of four to five tons per year but registers the highest sustained murder rate in the region (over 65 per 100,000 between 2000 and 2010).
An armed group reportedly stormed the building, which is in the centre of the city, and witnesses say they heard blasts and gunfire.According to a security official at the site, at least two staff members and two gunmen were killed, and the NOC chairman was evacuated.The attack comes as day after UNSMIL hosted a meeting in the western Libyan town of Zawiya, attended by the Libyan Government of National Accord, military and security chiefs, and armed groups present in around Tripoli.That meeting ended with a commitment from those present to uphold a ceasefire agreed on 4 September, and develop a plan for withdrawing armed groups away from areas which include sovereign institutions and critical infrastructure, across the capital.In a statement, UNSMIL described the assault on NOC – Libya’s primary source of national wealth – as “a blow against Libyans everywhere”, called on the country’s citizens to end conflicts and, in partnership with the international community, “eradicate the scourge of terrorism across the country.”The Mission expressed its deepest condolences to the families of the victims and wished a speedy recovery to the injured.
tchow: Out of RJ, Zion, Winslow and Tatum, who is the most likely to also believe the Earth is flat?natesilver: New Orleans is extremely flat, so I’m guessing it will be Zion after a few years.Check out our latest NBA predictions. natesilver: I mean, that’s how the system is supposed to work, right?neil: Well, I’ve always thought these tanking teams underestimated the luck involved in the lottery. Even under the old system.chris.herring: Last night’s outcome was probably about as solid as you could hope for from the league’s perspective if that’s the message you wanted to send. That being awful gives you a better chance but by no means guarantees you the very best — or even second-best — pick.tchow: Big win for Mr. Silver. (Adam, not Nate.)natesilver: And it’s not like the Knicks were categorically different than the Cavs, Suns or Bulls. They were just better at tanking. No. 3 is a comparatively good result vs. the rest of that group.BTW, someone should check the lottery ball codes to see what the results would have been under last year’s system.neil: Yeah, it’s weird to think of the Knicks as “winners” last night. But things could have been worse.chris.herring: The Knicks were the only team with the best lottery odds that didn’t fall out of the top four!natesilver: I really don’t get the losers talk, and I think it goes to show how people’s intuitions about probability aren’t very good.tchow: 14 percent means 100 percent, Nate!natesilver: People were treating it like 60 percent or something, I swear.neil: Knick fans’ expectations are always out of whack with reality, though… (This is a franchise that wins like the Mets but acts like it has the pedigree of the Yankees.)tchow: Neil, this is an NBA chat.chris.herring: I’m on record saying that I feel like the average Knick fan expects bad things to happen.neil: Maybe it’s more the New York media than rank-and-file fans, Chris.natesilver: This does leave open at least the tantalizing possibility of trading for Anthony Davis. If the Knicks do want to make a play for AD, this is one of the better scenarios for them. There’s no one who can trade Zion to the Pels since they already have him! The No. 3 pick is probably comparable to the best single asset that the Celtics and Lakers can offer. And if the Knicks get Kyrie Irving, maybe the Celtics don’t even try to get AD anyway.The Lakers do have the No. 4 pick, but at least based on the scouting consensus, there’s a big drop-off between 3 and 4. We’ll see if the Pelicans agree with that or not.chris.herring: I honestly don’t have a sense of what the Pelicans would prefer at this point.The Celtics would obviously be in play, based on their young talent and the draft picks they have. The Knicks just got the No. 3 pick and have two picks they got from Dallas in the Porzingis trade. Though those picks could end up being lower-end ones, depending on how the Mavericks are in the future. And then there are the Lakers, who just landed the No. 4 pick, plus all the guys they reportedly offered in February for Davis already.So it’s a combination of which players the Pelicans like, plus how they value the notion of future picks that would likely be lower in the draft, as opposed to higher ones they could make use of right now.natesilver: 🔥 Fun hot take: RJ Barrett could be the new Carmelo Anthony. High-volume, medium efficiency, good rebounder, mediocre effort on defense despite good athleticism. 🔥tchow: Looking at the different mock drafts, it does seem like there is a consensus on Top 3 (Zion, Ja, RJ in that order) and the fourth pick is immediately where you start seeing disagreements.neil: Which I think speaks to how few truly elite picks are in this draft class, Tony.chris.herring: Totally agreed.neil: But the Lakers can’t complain too much. They only had the 11th-best odds going on, so even moving up to fourth in a three-star draft is something.chris.herring: On Tuesday I walked past Gar Forman, from the Bulls’ front office, and he had a pretty grim look on his face after the team finished No. 7. Thought it was noteworthy that the Bulls’ John Paxson all but acknowledged that with a pick that low, the team was more likely to trade for a veteran as opposed to making it work with a rookie.It’s far more of a crapshoot outside of the Top 3.natesilver: We do know that the Pelicans didn’t like the Lakers’ pu pu platter back in February. And that was before Brandon Ingram’s DVT diagnosis. Although also before David Griffin took over, so maybe not as relevant now.chris.herring: There are a lot of options now for New Orleans. A lot of people were wondering out loud, too, whether getting Williamson might make the Pelicans more likely to find a deal for point guard Jrue Holiday, who could help a ton of teams as well.tchow: Chris, Paxson also had another pretty optimistic outlook on the results that I hadn’t thought of last night: chris.herring: Yeah, that quote infuriated Bulls fans here. It read like something out of The Onion.tchow: LOLneil: Do the Pels have more or less leverage in an AD trade now than they did at the deadline?natesilver: Weirdly, they have less, because there’s no one who can trade them Zion!chris.herring: Exactly. Likely less leverage but more flexibility in terms of the path they take, since they can feel pretty comfortable about building their future around him.natesilver: Are people too confident that Memphis will take Ja Morant and not RJ Barrett? They both have one glaring flaw (Morant: defense, Barrett: shooting), and historically, you’d rather go with the guy who can fix his shooting than a guy who is probably too undersized to ever be a great defender. Barrett’s also almost a year younger.Just to show how much a year can matter, compare Morant’s stats this year vs. last year: neil (Neil Paine, senior sportswriter): So we just witnessed what our friend Zach Lowe called the “wildest lottery ever.” The Zion-Williamson-to-the-Knicks (or its less-heralded cousin, Zion-to-the-Lakers) hype train gained a ton of steam when both teams were revealed to be in the Top 4 … and then it crashed and burned on live TV as the Lakers ended up at No. 4 and the Knicks at No. 3.Guys, take me through each of your experiences and emotions as you saw what unfolded.chris.herring (Chris Herring, senior sportswriter): I think we saw right away how crazy this new lottery system has the potential to be. By flattening out the worst teams’ odds of winning, you get a higher probability of something like last night playing out. It was insane at the actual lottery here in Chicago. There were these enormous gasps when they announced that the Bulls were going to pick seventh, the Suns were going to pick sixth, and the Cavs were going to choose fifth.natesilver (Nate Silver, editor in chief): I was at a fairly nice Italian restaurant with a friend who doesn’t really like basketball, and I made him pull out his phone along with my phone just so we could see who had the faster livestream. Unfortunately, this restaurant had a lot of wood paneling or something that was causing the signal to be pretty weak. Anyway, the livestream cut out right when it looked like the Knicks might be shut out of the Top 4 entirely, then it came back on and they were in the Top 4, and then right after that they got the No. 3 pick. As dumb as it sounds, the experience of having my expectations lowered made the No. 3 pick seem a lot better as a quasi-Knicks fan.Also, we ordered pasta for dessert, which people should try.tchow (Tony Chow, video producer): My fingers and toes were crossed from the time Boston’s 14th pick was announced. I started jumping up and down on my couch and screaming sometime between Phoenix’s sixth pick reveal and Cleveland’s fifth. There was a moment during that window that I thought 14 percent really meant something like 98 percent, and I was ready to buy my Zion Knicks jersey.chris.herring: Hahahahaha. Brutal.neil: Our colleague Chad Matlin had a great experience as well that he granted me permission to share:“a small anecdote from brooklyn last night: I’m walking home from dinner down Flatbush Ave and a man appears half a block behind me and starts violently screaming something, but I can’t quite make out what. he keeps screaming. I only catch snippets. “FUCKING!!!” “ALL!!!” “LOSING!“”” this goes on for 90 seconds as he crosses street aimlessly, screaming the same thing over and over. I finally piece it together: “ALL THAT FUCKING LOSING FOR NOTHING!!”And that’s when I found out the Knicks didn’t win the lottery.”Suffice to say, emotions were running high here in New York.chris.herring: LMAOnatesilver: I had run the numbers beforehand, and the No. 3 pick — in a draft where there’s a clear drop-off between Nos. 3 and 4 — is slightly above the expected value for the Knicks pick. Even if you think Zion is going to be reaaaaaaaaaaaly good, a 14 percent chance just isn’t that high.chris.herring: On some level, the lottery process and unveiling is really, really challenging for the average person — even for me — to follow along with if you aren’t focused on a single team and where they’re ending up.tchow: Yeah, Chris, in the hysteria last night, the graphics on TV really played a trick on me: They had the Top 4 picks in individual blocks on top, while 5 through 14 were listed below as they were revealing the picks. As the blocks were getting filled in, you saw the Lakers, then the Grizzlies and then the Pelicans, and I went, “Holy shit, we got No. 1!”chris.herring: One team being slotted lower than you expect is useful information, but it’s hard to know exactly who it benefits until there are only two or three teams left.Rachel Nichols was explaining it in real time, but it still takes a hot second or two to register what it all means, because of the pick swaps and protections, etc.neil: It’s kind of incredible that so many of us devote time to watching the unveiling of the results of pingpong balls based on probabilities, which each have obscure caveats (protections, etc), and it actually makes for compelling TV. The NBA is amazing.natesilver: Maybe they should reveal it one pick per day at a time over the course of the playoffs, sort of like an advent calendar.Think of all the opportunities for #content.chris.herring: I’m still kind of shocked that New Orleans ended up getting it. Makes a huge difference for them going forward. All this time, analysts were suggesting that they make a deal with the team that wins the lottery for Anthony Davis. Now they have the No. 1 pick AND Anthony Davis.neil: And David Griffin said their big priority is convincing AD to stay now. Is that feasible?chris.herring: It doesn’t seem the most feasible to me. You’d love for him to change his tune on that, but reports suggest that he won’t. It’s incredibly risky to gamble on the hunch that he will.natesilver: I think Zion might make it more likely that AD is traded, if anythingBecause now the franchise has something to play for and sell hope/tickets for, even without AD. So any scenario where they’re just being super stubborn and desperate is probably off the table.chris.herring: You don’t know whether Zion alone would be enough for them to make a huge jump in the next year, which is what you’d need to feel better about letting Davis test free agency.natesilver: New Orleans was one of just three teams to win the lottery that was neither undeserving, nor boring, nor annoying. So that was a win in my book. neil: And how does either affect where Mike Conley goes? They were shopping him pretty aggressively at the deadline but didn’t find the right deal.natesilver: I don’t think Memphis has any business keeping Conley either way.chris.herring: I’m interested in that question, too.natesilver: And I’m not sure it affects their pick much. If you want Ja, you can keep him and use Conley as a mentor if you want.chris.herring: Memphis is one of the smaller markets in the league, and because of that, I think they maybe hold on to players a year or two longer than they should. Perhaps because of the ties those fans feel to certain players.Morant is seemingly good enough where you draft him and then figure out the answer to that question with Conley later.natesilver: The Grizzlies have historically been a bit allergic to high-usage-rate guys, and both Barrett and Morant use a lot of possessions, so in some ways neither one feels like a natural Grizzly.chris.herring: Morant is a great passer, too, though, and averaged a double-double with assists. So I’d hope they make an exception in this case.tchow: If I were the Grizzlies, I’d take RJ.chris.herring: Wow. Knick fans would love if you became the Grizzlies’ GM.natesilver: The thing that’s really hard to project with Barrett is his defense. A lot of the comparables are pretty unflattering because people want to typecast him as Andrew Wiggins 2.0, maybe just because they’re both Canadian. But Wiggins was thought of as a guy who was going to be a plus defender, and he’s been pretty darn terrible instead. If Barrett’s a good defender, though, you start getting into a whole different set of comps, more along the lines of Jimmy Butler (if he tamps down the usage rate a bit) or Victor Oladipo.neil: Just goes to show how much defense — which I think can go overlooked for prospects at times (and is difficult to predict out of college) — can really alter a player’s pro trajectory. This, from ESPN’s mock draft on Barrett, sounds like it’s ripped out of the Wiggins scouting report: “he wasn’t the defender his physical tools suggest he should have been.”chris.herring: In fairness, Morant’s defense isn’t all that great, either. That’s part of what makes the No. 1 pick so easy, among other things.natesilver: Barrett was a much better rebounder, which counts for something. A much better and more active passer. And he was using a ton of possessions, which sometimes yields lower effort on defense. And Duke played a very tough schedule.I don’t know. If Barrett had shot 38 percent from three instead of 31 percent, I think people would be talking about him and Williamson like it’s … I don’t know, the Kevin Durant/Greg Oden draft or something. And of course, you can’t just disregard the difference between 38 percent and 31 percent. But he’s a pretty spectacular prospect if he learns how to shoot.chris.herring: It’s so hard to tell in college. The shooting is somewhat predictive. But even if he had shot 38 percent this year, I think there would be room to ask whether it was completely real.I remember Justise Winslow shooting a pretty healthy percentage from out there during his lone year at Duke, but so many of the makes came with Jahlil Okafor being doubled in the post, which left Winslow wide-open a lot of the time. And then he initially struggled from three once he came into the league, which was what many folks predicted.natesilver: The low free-throw percentage is troubling for Barrett.Like, Jayson Tatum — a guy who’s been a much better 3-point shooter as a pro than people thought — shot free throws pretty darned well in college. Barrett didn’t.chris.herring: Completely agreed. That tends to have solid predictive value.neil: It’s also worth remembering that Barrett was actually the No. 1 prospect in that star-studded class going into their freshman seasons. But I’ve seen studies that indicate the weight given to even one year of college should far outweigh our priors for prospects coming out of high school.tchow: This chat is just becoming a conversation about how Duke players perform in the NBA.chris.herring: Seems fair to me: neil: SO many people were looking at that!tchow: It must have meant something!neil: NBA conspiracies are the best.chris.herring: It seemed that might have been his preference.tchow: Can you imagine all the “it’s rigged” people if the Hawks did end up getting No. 1 after the logo double tap?chris.herring: Can’t remember too many people WANTING to go to Atlanta, but I actually hoped he’d end up there after that.neil: 😢tchow: Zion with Trae Young is really intriguing.But if we’re playing alternate universes and what-ifs, can we play “what if Zion did go to the Knicks?” Neil thinks owner James Dolan would have somehow messed it up anyway. I disagree.neil: Right, my take was always that he should be happy he didn’t go to the Knicks. Everything that franchise touches goes to ruin.tchow: But he could have changed that, Neil!chris.herring: ESPN’s Adrian Wojnarowski was reporting pretty adamantly that the Knicks wouldn’t have traded him. So it seems like they would have moved forward with him, and then gone into free agency shooting for the stars.natesilver: I think it would have been dumb to trade him. Like, more dumb than people realize. When you consider the contracts, and that the Pelicans don’t rally have much leverage, I think you can even argue that Zion straight up is TOO MUCH for AD, without all the other assets that the Knicks were likely to have to throw into the deal. But, anyway, I guess we don’t have to worry about that now.chris.herring: I agree. You’re going to want and need cost-controlled contracts for when you get other stars, anyway. Having Zion would allow you to do that.tchow: Is it wrong of me to think that this is even more proof that the lottery was rigged? Like, the results were so much the complete opposite of what you thought a “rigged” one would look like that it’s almost too opposite. Am I making sense? Like, the results seemed to be what someone would produce to prove that something wasn’t rigged when it actually was.natesilver: Tony I think you’re overthinking this just a liiiiiiiiiiiiittle bit.chris.herring: LOLneil: Of course, they did invite some of this rigging speculation by having Patrick “Frozen Envelope” Ewing there to represent the Knicks.chris.herring: As someone who’s been in the room, it’s not rigged. They go to great lengths to let people watch it. And make the actual process available on YouTube shortly after.I think the variance is going to be really wild going forward because of how they’ve flattened out the odds for the worst few teams, though. And honestly, it will make it more fun and heartbreaking.tchow: I know it’s not rigged. But……Just kiddingneil: But yeah Chris, I wanted to ask about that. Did we see the death of tanking last night?Look at how much the results at the top differed from the ranking in order of worst records: tchow: Nate, I disagree with so much of that Venn diagram.natesilver: Hahaneil: As an Atlantan who also once worked for the Hawks, I guess I’ll take “basically OK.”chris.herring: Neil, I’m sure die-hard Hawks fans were disappointed last night. Basketball people seem to universally feel that would’ve been his best fit.Did you all see the video of Williamson hitting the Hawks logo twice before the lottery began?
The drug offers new hope for Alzheimer’s patients Credit:Alamy The Phase 1 trial, reported in the journal Science Translational Medicine, recruited just 32 patients and was chiefly concerned with dosage and safety. However the trial showed that amyloid was reduced nearly entirely in some cases, and the effect increased with higher doses.Dr Clare Walton, research manager at the charity Alzheimer’s Society, said: “Amyloid plaques are a key hallmark of Alzheimer’s disease and most recent efforts to find new dementia treatments focus on reducing the production of amyloid or clearing plaques out of the brain.”This study describes a new drug that reduces the production of amyloid in people with dementia and, importantly, it appears to be safer than similar drugs that have come before. This finding has paved the way for much larger clinical trials that are currently under way, and we very much look forward to the results of these in the coming years.” A pioneering new drug has been shown to clear away sticky clumps of plaque in the brain, thought to be a primary cause of Alzheimer’s, and is now in final trials.The drug, verubecestat, is one of a number being tested by pharmaceutical companies in a race for the first treatment that can halt or reverse the disease.Results from a small Phase 1 study confirm that verubecestat can reduce levels of beta-amyloid, a protein fragment that accumulates in sticky deposits or “plaques” in the brains of Alzheimer’s sufferers by up to 94 per cent.Most importantly, it appeared to produce no severe side effects. Earlier experiments with drugs that work the same way, by targeting an enzyme linked to amyloid build-up, were abandoned when they were found to cause liver and nerve damage.It is the first of its kind to make it to phase 3 trials, which will give a conclusive indication about whether it is effective.Dr Rosa Sancho, from the charity Alzheimer’s Research UK, said: “It has been over a decade since a new drug was licensed for the treatment of dementia, so we urgently need new medicines that can provide real benefit for people living with dementia.” Currently there are medicines available that can alleviate some of the symptoms of the disease, but nothing capable of halting or slowing its progress. That situation may be about to change if drugs such as verubecestat pass the stiff tests of safety and effectiveness imposed by medicine regulators. Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily Front Page newsletter and new audio briefings.
Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)RelatedERC engages national stakeholdersJuly 17, 2018In “latest news”IAC raises several concerns with President GrangerJune 19, 2015In “Politics”Investigation into employment practices at GECOM in progress- ERCOctober 8, 2018In “latest news” The newly re-constituted Ethnic Relations Commission (ERC) on Wednesday continued its meetings with stakeholders.ERC Commissioners in discussion with some representatives of the Indigenous People ConstituentThe body met with representatives of the Indigenous, East Indian and African Guyanese constituents at Herdmanston Lodge, Georgetown to get a firsthand account of issues confronting members of the various groups.According to the ERC in a statement, during the engagements, important concerns were raised and suggestions offered with commitments to work together in promoting harmony and good relations across the country.Part of the delegation of the Afro-Guyanese Constituent during a meeting with the ERCThe ERC said it is in the process of spreading and fostering awareness of its twenty-four (24) functions listed in Article 212D of the Constitution and to seek possible inputs from stakeholders in support of the execution of its mandate.The meetings on Wednesday were all chaired by Deputy Chairman Major General (ret’d) Norman McLean and six ERC Commissioners were present.ERC Commissioners pose with representatives of the Indo-Guyanese ConstituentTo date, the ERC has met with President David Granger, Leader of the Opposition, Dr Bharrat Jagdeo, the Private Sector Commission, the Ambassador and team from the European Union (EU), Ambassador and representatives of the ABC Diplomatic Community and representatives of the three major Religions.The ERC said it is also scheduled to meet with the Inter-Religious Organisation (IRO) andrepresentatives of Women and Youth Constituents.
The average household uses 32 gallons of water each day just from the taps. The Altered:Nozzle aims to reduce that to less than one gallon using a new water-saving design. According to the creators of Altered:Nozzle, attaching this device in place of your standard faucet nozzle will reduce water usage by a whopping 98% without sacrificing functionality. The project is on Kickstarter, and it’s already smashed through its original goal.Altered:Nozzle is essentially an extremely aggressive aerator that attaches to your existing faucet. As water flows through the faucet, Altered:Nozzle breaks it up into millions of tiny droplets (they call this atomizing). A traditional faucet puts out much more water, but it comes out in a constant stream, much of which just splashes off anything in its path. You can make contact with essentially all the water coming out of the Altered:Nozzle because it has more total surface area as tiny droplets. The promo video shows people doing a variety of household activities (and a suspicious amount of hand washing) with the atomized water spray. Altered:Nozzle has a secondary mode, though. With a twist of the nozzle, it outputs a more directed spray. This uses more water, but it lets you do things like fill up a container without waiting ages. It still uses 75% less water than a regular tap, though.The designers were looking to get about $30,000 in Kickstarter backing for the Altered:Nozzle. As of now, it’s over $350,000. Making a lot on Kickstarter is by no means a guarantee that something will live up to the hype (or even ship to backers), but the design of the Altered:Nozzle is complete. It’s not a hypothetical product. If you want one of your own, it’ll cost you about $44 and it ships in December.
‘Star Wars Pinball’ Has Your Favorite Brand in Ball FormSNES Games Officially Come to Nintendo Switch What a weird emotional roller coaster Mario + Rabbids: Kingdom Battle has taken us on. Rumored before the Nintendo Switch itself was even revealed, gamers were hesitant to see Nintendo’s beloved plumber team up with Ubisoft cretinous Rabbids. However, after Shigeru Miyamoto himself helped unveil the game at E3, minds began to open.Our first few hands-on sessions confirmed that the strangest thing about the game isn’t even its mascot mash-up but the fact that it is a tactical strategy game in the style of X-COM. However, while the mechanics showed an absurd amount of the promise, the early stages left me unsure of whether or not the game would be challenging enough to require so much complexity. But now that I’ve spent a few hours with the game’s various modes ahead of its launch later this month, I can safely say a sentence as silly as Mario + Rabbids: Kingdom Battle is a serious strategy game.I played a few matches in the first of four worlds, the standard jungle environment, just to refresh myself with the mechanics. Each round lets you take turns controlling three different Mario and/or Rabbids characters either taking out all the enemies or reaching a designated safe zone. There’s much to consider with each action. Should I leave myself out in the open and guarantee a hit or move behind cover and flip a coin? Should I travel across the map using Rabbid pipes, or leapfrog off of my teammates using the team jump technique? And when should I activate my passive ability like Rabbid Peach’s healing field or Rabbid Yoshi’s protective shield?In the early levels, you won’t need to stress too much about your plethora of strategic options, even if you do appreciate that they are there. However, I then jumped into the game’s penultimate world and was forced to use every tool available to me just to survive. This was a spooky, Luigi’s Mansion-esque world full of Boos that spirit you across the map if you touch them, ghoulish Rabbid grunts that emerge from the ground, and coffin-wielding Rabbid heavy soldiers you must flank to outmaneuver their impenetrable shields. This is exactly the kind of in-depth, brain-scratching problem solving I wanted from this game.Describing any particular tactic in Mario + Rabbids: Kingdom Battle sounds absurd given the subject matter but let’s do it anyway. Because Luigi had taken damage in the previous skirmish, I brought well-rounded Mario, passive healer Peach, and powerful Rabbid Mario into battle. Before starting I viewed the overhead map to plot out a course to the safe zone. I then customized my characters’ weapons and stats.The sheer density of what I could do was nearly overwhelming, even with the game’s advice, but in a great way. Increasing Peach’s range seemed smart since when she lands from jumping allies around her get healed. Rabbid Mario’s spread gun with a burn effect would come in handy, as long as allies weren’t caught in the blast. And if I managed the cool-down correctly, I could wallop nearby foes with Mario’s hammer melee sub-weapon.Even with all my planning, I had to adapt to what the game threw at me. If Mario got taken out quickly due to a health-draining vampire attack so be it. If there was an opportunity to dash attack into three foes at once with Rabbid Mario then lucky day. Between movement, attacking, and using a technique, there are a lot of actions you can perform with each character during any given move. And considering how exponentially their movement options increase when they work together, this later level demanded I learn how to control space. I used Rabbid Mario’s magnet dance to pull enemies out of cover before having Peach throw a Splinter Cell-themed bomb that bounced them out of the arena. I love it when a plan comes together.After my second and more successful attempt at that battle I solved one of the game’s light puzzles that pop up in the exploratory phases between the fighting. I pressed switches to redirect light beams around. It was pretty low-impact, like an early shrine in The Legend of Zelda: Breath of the Wild, but I needed the breather after the satisfying mental stress of the last encounter.From there it was time to fight the boss, a spotlight-hogging phantom Rabbid who wails opera with Mario parody lyrics presumably composed by beloved Rare musician Grant Kirkhope. Between this and Super Mario Odyssey, this is the year of vocal songs in Mario games. I won’t say how I (nearly) took down this boss, but again the fight made great and challenging use of the tactical tools you have available (and presumably will become more skilled with while playing the game from the beginning).I finished my demo by playing two of the game’s co-op missions with a member of the development team. Each holding a sideways Joy-Con (which presents some annoying control compromises so nab a second Pro Controller if you can) we each controlled two characters. Already, having four characters to collectively deal with instead of three opens up even more tantalizing, strategizing possibilities. We had Luigi hang back and snipe bomb-throwers who crossed his line of sight using his Mario Kart 8 meme-referencing Death Stare ability. We then bounced Mario off of Rabbid Peach across a chasm to enemies isolated on a higher plateau. I consistently underestimated the horizontal and vertical range I could take advantage of.Standard single-player battles usually only took a few minutes, making them great for portable play on the Nintendo Switch. But this co-op mission teeming with enemies was much longer, more conducive to longer play full of communication with a friend on the couch. Tom Clancy’s Snipperclips. Co-op was a ton of fun, but the single player is the star of a show. There will also be challenge maps where you can experiment with new strategies and weapons, including weapons you unlock through Amiibo figures. With recent marquee Switch games like Mario Kart, Arms, and Splatoon 2 focusing on multiplayer, playing a big single player game immersed on a TV or the Switch’s gorgeous screen was a refreshing change of pace.Finally, I got to chance to chat with Mario + Rabbids: Kingdom Battle creative director Davide Soliani, now famous for getting touchingly emotional when Miyamoto gave him a shout out during the game’s E3 reveal. I learned some fascinating tidbits about the project. The shockingly pretty cartoon visuals are powered by the Snowdrop engine. That’s also the tech that runs The Division, a very different game on different platforms. But getting the engine to run on the Nintendo Switch once hardware arrived only took a few weeks. And while the team began developing the game before the knew exactly what the Switch was, they had a hunch it might be smart to tailor the game for a portable experience.I can confirm Rayman won’t be in the game because he is now once again his own #brand separate from the Rabbids. The team hopes this game can raise the Rabbids’ profile as far as quality video games go. Standing next to a character with a track record as sterling as Mario’s is probably strong motivation to push yourself. I’ve loved some Rabbids games in the past, including Rabbids Go Home on the Wii aka French Katamari Damacy. But Mario + Rabbids is the first Rabbids game in nearly a decade with some actual promise.As for the weird Mario side of things, while this wasn’t a conscious choice, this strategy RPG’s more comedic take on the Mushroom Kingdom reminded me of the tone of other Mario RPGs like Paper Mario and Mario & Luigi: Superstar Saga. As a huge Nintendo fan, Soliani had of course played all these games. And if this game is successful, he would love to be involved in future, even stranger Nintendo/Ubisoft collaborations. I would love to see how upsetting a Rabbid Waluigi would be.Turn-based strategy games like X-COM, Fire Emblem, and Advance Wars are some of my favorite games. They’re like chess but with animation. So I would have been extra disappointed if Mario + Rabbids: Kingdom Battle was a bad, shallow take on the genre solely designed for brand synergy. But from what I’ve played that isn’t the case at all. Not since Ghost Recon: Shadow Wars on the 3DS (developed by X-COM mastermind Julian Gollop) has Ubisoft surprised me with a strategy game on a Nintendo platform as seemingly deep and cool and random as this. Mario + Rabbids: Kingdom Battle for the Nintendo Switch is the real deal.Want to learn more? Here’s everything you need to know about the Nintendo Switch.Buy it now!The Legend of Zelda: Breath of the WindNintendo SwitchProtect Your Nintendo Switch With These Awesome CasesView as: One Page Slides1/61. Mario and the Raving Rabbids have joined forces to make a promising video game.2. Rabbid bosses put weird spins on classic Mario iconography.3. This turn-based strategy game resembles classics like X-COM.4. I’m very excited for this game.5. The surprisingly vast amount of movement and combat options really lets you plan out elaborate strategies. 6. Bizarre premise aside, Mario + Rabbids: Kingdom Battle is shaping up to be a fun, deep, beautiful tactics game for Nintendo Switch.Let us know what you like about Geek by taking our survey. Stay on target
By Sulayman Bah Gambia Scorpions yesterday made bit of a climb according to Fifa’s March ranking. The Scorpions who are without a coach since Bonu Johnson’s contract nullification by the Youth and Sports Ministry climbed one step moving up from 169 to 168 in the world ahead of Bermuda, Pakistan and Laos, virtual football unknowns.The ranking based on teams’ activeness including friendly matches hasseen Gambia –one time 100th best national football team – on a freefall on the ladder for lack of test matches with the rating only improving this month.A similar slight upping follows in Africa with Gambia ranked 46th in a 54-nation standing topped by Afcon title winners Ivory Coast.Meanwhile, Germany leads the way at the top in the globe ahead of Argentina, Colombia, Belgium and Netherlands on 2nd, 3rd, 4th and 5th.]]>
MIAMI GARDENS, FLA. (WSVN) – A man who led people on a foot chase was arrested for allegedly firing a shot before crashing in Miami Gardens.The suspect crashed his Jeep near Miami Gardens Drive and Northeast Second Avenue, Thursday.Miami Gardens Police said after he crashed his vehicle, he fled on foot.Officers had their guns drawn at a nearby gas station and apprehended the suspect.Copyright 2019 Sunbeam Television Corp. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Microsoft axed a whole bunch of employees and projects last week, including the staff developing original content for Xbox One. But fear not, the only original content anyone cared about survived the cut. Halo: Nightfall is heading to the Xbox One as a part of the Halo: Master Chief collection later this year, and it paints an interesting picture for what can be expected in Halo 5: Guardians.We’ve known for a little while now that Ridley Scott was lending his twisted mind to the Halo universe in order to give everyone something to drool over while we wait for a new Halo game. While we’ve had great titles like Titanfall and soon Destiny to keep us busy, a Halo game is long overdue on Microsoft’s new box.This “first look” at Halo: Nightfall introduces us to Jameson Locke, who we now know is the character in glossy black Spartan-like armor on the cover of Halo 5.More and more it’s starting to look like The Arbiter and Locke are working together. The aim being to find Master Chief in order to stop an artifact that was originally being hunted for by the Covenant as a sort of last ditch effort to win the war against the UNSC.The element being described in this video targets and eliminates humans, and it apparently works over a great distance. This, combined with finally learning more about the ONI group, makes for a very interesting story to lead us into the next game.
EchoPixel Showcases NextGeneration Surgical Planning With True 3D Interactive Mixed Reality Software
A 3-D printed model (left) and a model constructed in augmented reality (right), both of a kidney with a tumor. In both models, the kidney is clear; the tumor is visible in purple on the AR model and in white on the 3-D printed model. Photo courtesy of Nicole Wake, Ph.D. Technology | Virtual and Augmented Reality | June 04, 2019 Ann Arbor Startup Launches Augmented Reality MRI Simulator SpellBound, an Ann Arbor startup specializing in augmented reality (AR) tools for children in hospitals, has officially… read more Related Content Image courtesy of Philips Healthcare News | Medical 3-D Printing | August 08, 2019 RSNA and ACR to Collaborate on Landmark Medical 3D Printing Registry The Radiological Society of North America (RSNA) and the American College of Radiology (ACR) will launch a new medical… read more Technology | Virtual and Augmented Reality | June 10, 2019 Medivis SurgicalAR Gets FDA Clearance Medivis announced that its augmented reality (AR) technology platform for surgical applications, SurgicalAR, has… read more Feature | Advanced Visualization | July 02, 2019 | By Jeff Zagoudis Augmented Reality Versus 3-D Printing for Radiology Three-dimensional (3-D) printing and… read more News | Advanced Visualization | January 08, 2018 EchoPixel Showcases Next-Generation Surgical Planning With True 3-D Interactive Mixed Reality Software Latest version of True 3-D expands supported modalities beyond CT and MR to include ultrasound with Doppler and C-arm views Technology | Artificial Intelligence | June 20, 2019 TeraRecon Receives First-of-Kind FDA Determination for Northstar AI Results Explorer Advanced visualization and artificial intelligence (AI) technology provider TeraRecon has successfully completed a U.S… read more Technology | Advanced Visualization | June 13, 2019 Materialise Receives FDA Clearance for Cardiovascular Planning Software Suite Three-dimensional (3-D) printing software and solutions company Materialise has received U.S. Food and Drug… read more News | Advanced Visualization | July 03, 2019 TeraRecon Unveils iNtuition AI Data Extractor Artificial Intelligence (AI) and advanced visualization company TeraRecon announced its new iNtuition AI Data Extractor… read more Henry Ford Hospital’s ViewRay MRIdian linear accelerator system allows real-time MRI-guided radiotherapy. Shown is the support staff for this system. In the center of the photo is Benjamin Movsas, M.D., chair of radiation oncology at Henry Ford Cancer Institute. Second from the right is Carri Glide-Hurst, Ph.D., director of translational research, radiation oncology. Technology | Neuro Imaging | August 07, 2019 Synaptive Medical Launches Modus Plan With Automated Tractography Segmentation Synaptive Medical announced the U.S. launch and availability of Modus Plan featuring BrightMatter AutoSeg. This release… read more Feature | Molecular Imaging | July 01, 2019 | By Sharvari Rale Transformations in Molecular Imaging Herald Entry to Novel Applications Diagnostic procedures have always been a cornerstone of early prognosis and patient triaging. read more January 8, 2018 — EchoPixel showcased the latest version of True 3D, its interactive, mixed reality software solution at the 103rd Annual Radiological Society of North America (RSNA) meeting, Nov. 26-Dec. 1, 2017, in Chicago. True 3D was featured in the Virtual Reality Showcase in the RSNA Learning Center.The software offers next-generation surgical planning capabilities. The True 3D Viewer software enables physicians and surgeons to interact with medical images the way they would with physical objects in the real world. The system leverages DICOM image data to create life-size holographic versions of organs, blood vessels and other structures, allowing physicians to rotate, resize, dissect and make incisions to virtual patient-specific anatomy. This capability enables physicians to read images faster, leading to faster diagnoses and provides enhanced pre-operative planning.Version 1.6.2 expands supported modalities beyond computed tomography (CT) and magnetic resonance imaging (MRI) to include ultrasound with Doppler and C-arm fluoroscopy images. The integration of blood flow, or hemodynamics data, into 3-D representations provides structural and functional data, expanding the clinical utility of ultrasound. For example, this may help better assess implantable device sizing, fibroid and uterine vascularity as well as fetal heart assessment.By supporting C-arm views, True 3D software can show a fluoroscopy image in 3-D, as well as use other imaging datasets to create a 3-D digital reconstruction radiograph (DRR), enabling clinicians to better understand the focal point, location and orientation of fluoroscopy images. Visualizing patient anatomy and overlaid fluoroscopy images in the operating room (OR) and cath lab, can help clinicians determine which anatomic structures are in front of or behind the fluoro image plane, as well as better understand where the catheter is in relation to the fluoro plane and patient anatomy.The latest version of True 3D software also features a new reporting structure specifically designed to help improve the translation of images and expand the surgical planning services radiologists provide surgeons. Key Bookmark Scenes (KBS) files provide a graphical, anatomically meaningful 3-D model that enables the surgeon to visualize complex spatial relationships of the patient’s anatomy and pathology.The virtual patient data is presented in the same view and orientation they would see in the OR. Additionally, the radiologist can create a surgical plan with key step instructions and visualizations. In following the KBS surgical plan, the surgeon can click on the “next step” button and the image data is placed on the current position defined in the plan. This is analogous to using an internet maps app to augment driving directions with 3-D visualizations of key landmarks along the route.The KBS file can be saved and pushed to the picture archiving and communication system (PACS) for the surgeon to refine the surgical plan and use as a reference during the procedure. The surgeon can interact with the virtual patient’s image data, as well as create cross-sections, label key structures and take measurements. For example, the surgeon is able to use interactive tools to visualize different stages for a dissection, surgical procedure or implantable device sizing and implantation.For more information: www.echopixel.comRelated ContentEchoPixel Announces True 3-D Print SupportEchoPixel True 3D Viewer Gives Surgeons 3-D View Inside the Human BodyBlending The “Ologies” FacebookTwitterLinkedInPrint分享 Feature | Henry Ford Hospital | May 21, 2019 | Dave Fornell, Editor Innovations in Radiotherapy and Radiology at Henry Ford Hospital Henry Ford Hospital thought leaders regularly speak at the radiation oncology and radiology conferences about new res read more
in Daily Dose, Headlines, News Single-Family Rental: The Industry’s Next Big Thing Single Family Rental Market 2016-11-02 Seth Welborn November 2, 2016 735 Views With the homeownership rate in the U.S. currently near a 50-year low, there are now approximately 14 million single-family rental homes in the country.In order to tap into this multi-trillion dollar asset class, many investors and others in the single-family rental space gathered at the Second Annual Five Star Single-Family Rental (SFR) Summit this week in Frisco, Texas, for two days worth of panels from industry experts, Ted Talks, and networking.Five Star President CEO Ed Delgado noted that the industry goes in cycles—15 to 20 years ago, the buzzword was loss mitigation, to the point where companies were being launched just to handle deeds-in-lieu and short sales. Those have largely disappeared, and the popularity of the single-family rental market has exploded in recent years as foreclosure rates have declined. Now, builders are creating entire subdivisions and construction strategies around building single-family homes for the purpose of renting.Wednesday morning at the SFR Summit featured experts discussing property acquisition—sharpening your acquisition strategy, the pros and cons of portfolio and single-asset acquisition, and when to consider investing.“My main goal is to shed light on other opportunities in our industry and to show these buyers on any scale how to acquire assets in different, unique platforms,” said Brennan Reid, CEO of Joyce Reid Capital, which specializes in tax sales investments. “The main thing you hear at all these conferences is lack of inventory, lack of inventory, lack of inventory. There’s a lot of inventory out there that people don’t even know exists, and it’s our goal to expose that.”Wednesday afternoon, industry leaders specializing in disposition strategies took the stage to discuss how to best ensure a portfolio remains agile in a shifting SFR marketplace as well as how to evaluate a portfolio to ensure maximum profitability.“I think trends we see for the big picture are the large institutions are selling off their C-class portfolios, and because of the emergence of SFR lending, high net worth individual business owners viewing real estate as still attractive even at high traditional values then we have seen in years past,” said Paul Yazbeck, VP Investment Sales for SVN. “They are still able to purchase properties that make sense for them and earn returns that are sufficient.”The speakers zeroed in on incorporating the appropriate disposition strategy in an investment plan which could make the difference between profit and taking a loss, and exploring the varies strategies industry leaders are already implementing.The funding session of the SFR Summit on Wednesday included such topics as selecting the right funding product for your portfolio and must-have resources for lenders and borrowers.(Editor’s note: The Five Star Institute is the parent company of MReport and TheMReport.com) Share
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? “but nothing anyone in the area needs to worry about. Mike Mbama Okiro has urged the newly promoted officers to rededicate themselves to the service of their fatherland while assuring them of their basic entitlements and regular promotions. former Commissioner of Police, The Ben Mor-directed video following Coldplay singers on a cultural tourist jaunt to Mumbai received immediate criticism for cultural appropriation on U. So far, they can’t say anything else, Vice Chairman; Michael Oladipo, long a leader in featuring healthier. Doctors were immediately drafted to the scene where she was confirmed dead.